Fluoroscopic coronary calcification and exercise stress test in asymptomatic elderly Asian-Indians.

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dc.contributor.authorSingh, Nishith Ken_US
dc.contributor.authorNarang, Rajiven_US
dc.contributor.authorDey, Aparajit Ben_US
dc.date.accessioned2008-07-27en_US
dc.date.accessioned2009-05-27T04:22:27Z
dc.date.available2008-07-27en_US
dc.date.available2009-05-27T04:22:27Z
dc.date.issued2008-07-27en_US
dc.description.abstractOBJECTIVE: Provide preliminary data on prevalence and functional significance (association with atherosclerotic risk factors and stress test positivity) of fluoroscopically detected CAC (Coronary Artery Calcification) in asymptomatic elderly Indian-Asian. DESIGN: Prospective observational study. SETTING: Outpatient services at 1000-bed tertiary care hospital in Northern India. PATIENTS: 100 sedentary elderly (>60 years) Asian-Indian subjects (70 males, 30 females, age 65.9 +/- 5.1 years) with no history of CAD (asymptomatic). METHODS: CAC assessment was done using high intensity cine fluoroscopy and semi quantitative CAC scoring (scores 0-3) in all subjects (n = 100). Risk factor profile (diabetes, hypertension, smoking, serum lipids, body-mass index, waist-hip ratio) documented for all subjects. In 50 (the latter half of 100) consecutive subjects (29 males and 21 females, age 64.2 +/- 4.9 years), exercise stress test (treadmill test, TMT) was also done using standard Bruce protocol. RESULTS: 92% (84.8-96.1, 95% CI) had fluoroscopic calcification and there was no significant association of higher CAC scores and risk factors, except for a positive trend with serum total cholesterol (p = 0.086). 20% (11-33.2, 95% CI) tested positive on exercise stress test and a positive trend (OR = 7.2, 95% CI = 0.8-63, p value = 0.067) with higher CAC scores was seen. CONCLUSION: High prevalence of fluoroscopic CAC and stress test positivity was observed in asymptomatic elderly Asian-Indians. The newly observed positive trend with increasing total cholesterol levels and stress test positivity highlights the importance of fluoroscopic CAC in asymptomatic elderly and should be corroborated with larger studies.en_US
dc.description.affiliationDepartment of Internal Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. nishith_singh2004@yahoo.co.inen_US
dc.identifier.citationSingh NK, Narang R, Dey AB. Fluoroscopic coronary calcification and exercise stress test in asymptomatic elderly Asian-Indians. Indian Heart Journal. 2008 Jul-Aug; 60(4): 302-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4278
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAnthropometryen_US
dc.subject.meshCalcinosis --diagnosisen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshCoronary Artery Disease --diagnosisen_US
dc.subject.meshExercise Testen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluoroscopyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.titleFluoroscopic coronary calcification and exercise stress test in asymptomatic elderly Asian-Indians.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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