Effect of antituberculosis treatment on cardiopulmonary responses to exercise in miliary tuberculosis.

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dc.contributor.authorSharma, S Ken_US
dc.contributor.authorAhluwalia, Gautamen_US
dc.date.accessioned2006-10-13en_US
dc.date.accessioned2009-05-27T07:24:24Z
dc.date.available2006-10-13en_US
dc.date.available2009-05-27T07:24:24Z
dc.date.issued2006-10-13en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Tuberculosis (TB) is a major health problem in the developing world. In this preliminary study, we report the effect of antituberculosis treatment (ATT) on cardiopulmonary responses to exercise in patients with miliary tuberculosis (MTB). METHODS: The prospective study of cardiopulmonary responses to exercise in patients with MTB within one month of starting (n=14), on completion of ATT (n=7) and in 15 healthy subjects using the incremental exercise test was performed on a bicycle ergometer. RESULTS: In MTB patients, mean body mass index (BMI), exercise duration (3.1 vs 4.6 min), work load (63 vs 91.4 watts), resting tachycardia, tachypnoea and the mean oxygen saturation improved significantly (P<0.05) with ATT. Mean oxygen consumption (V . O(2)) at anaerobic threshold (546.7 vs 580.9 ml/min) and maximum exercise (1008.1 vs 1022 ml/min) were similar before and after ATT. In MTB patients, post-treatment mean body weight, BMI, resting heart rate, respiratory rate and oxygen saturation during maximum exercise were similar, but exercise duration (4.6 vs 6.2 min, P<0.05), work load (91.4 vs 145.5 watts, P<0.05), V . O(2) and oxygen pulse were significantly lower as compared to healthy subjects. INTERPRETATION & CONCLUSION: In MTB patients, though there was significant improvement in clinical parameters, functional abnormalities persisted on exercise testing after completion of ATT. As most patients with MTB are young and economically active, these observations obviously have long-term implications for these individuals.en_US
dc.description.affiliationDivision of Pulmonary & Critical Care Medicine, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. sksharma@aiims.ac.inen_US
dc.identifier.citationSharma SK, Ahluwalia G. Effect of antituberculosis treatment on cardiopulmonary responses to exercise in miliary tuberculosis. Indian Journal of Medical Research. 2006 Oct; 124(4): 411-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20576
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntitubercular Agents --pharmacologyen_US
dc.subject.meshCardiovascular System --physiopathologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshExercise --physiologyen_US
dc.subject.meshExercise Testen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRespiratory Mechanicsen_US
dc.subject.meshTuberculosis, Miliary --drug therapyen_US
dc.titleEffect of antituberculosis treatment on cardiopulmonary responses to exercise in miliary tuberculosis.en_US
dc.typeJournal Articleen_US
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