Photosensitization of cultured cells and viruses by pyrene lipids.

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dc.contributor.authorGatt, Sen_US
dc.contributor.authorDinur, Ten_US
dc.contributor.authorAbou-Rabia, Sen_US
dc.contributor.authorKotler, Men_US
dc.contributor.authorFibach, Een_US
dc.date.accessioned1990-12-01en_US
dc.date.accessioned2009-05-27T09:53:09Z
dc.date.available1990-12-01en_US
dc.date.available2009-05-27T09:53:09Z
dc.date.issued1990-12-01en_US
dc.description23 references.en_US
dc.description.abstractAdministration of pyrene-linked fatty acids and lipids to cultured cells or an enveloped (vesicular stomatitis) virus induced photosensitization which, following irradiation with a long ultra-violet light (LUV), resulted in killing of the cells and loss of the infectivity of the virus with the following specific effects. (i) LUV illumination of the pyrene-sphingomyelin administered cultured skin fibroblasts derived from normal individuals and patients with Niemann-Pick disease permitted selective killing of the latter. (ii) Similarly LUV illumination of pyrenedodecanoic acid (P12) incubates of leukemic cell lines mixed with human bone marrow cells permitted selective killing of the former. (iii) LUV illumination of P12 incubates of vesicular stomatitis virus decreased the infectivity of the virus by up to 12 logs.en_US
dc.description.affiliationDepartment of Membrane Biochemistry, Hebrew University, Hadassah School of Medicine, Jerusalem, Israel.en_US
dc.identifier.citationGatt S, Dinur T, Abou-Rabia S, Kotler M, Fibach E. Photosensitization of cultured cells and viruses by pyrene lipids. Indian Journal of Biochemistry & Biophysics. 1990 Dec; 27(6): 359-62en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28852
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshCell Survival --drug effectsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshFibroblastsen_US
dc.subject.meshLauric Acids --pharmacologyen_US
dc.subject.meshLeukemia, Myeloid --pathologyen_US
dc.subject.meshNiemann-Pick Diseases --pathologyen_US
dc.subject.meshPyrenes --pharmacologyen_US
dc.subject.meshSphingomyelins --pharmacologyen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshUltraviolet Raysen_US
dc.subject.meshVesicular stomatitis Indiana virus --growth & developmenten_US
dc.titlePhotosensitization of cultured cells and viruses by pyrene lipids.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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