Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma.

Simple item page
dc.contributor.authorZhu, Jing
dc.contributor.authorCao, Yong
dc.contributor.authorLi, Kaiyan
dc.contributor.authorWang, Zhengyun
dc.contributor.authorZuo, Peng
dc.contributor.authorXiong, Weining
dc.contributor.authorXu, Yongjian
dc.contributor.authorxiong, shengdao
dc.date.accessioned2012-01-12T06:55:12Z
dc.date.available2012-01-12T06:55:12Z
dc.date.issued2011-09
dc.description.abstractObjectives: We sought to determine whether the aryl hydrocarbon receptor (AhR) and interleukin (IL)-22 may be involved in the pathogenesis of the peripheral blood mononuclear cells (PBMCs) in allergic asthmatic patients and whether their expression may be related to the severity of the disease. Methods: Blood samples were obtained from each subject with allergic asthma (n =18), controlled asthma (n =17) and healthy controls (n =12) respectively. The PBMCs were collected for AhR mRNA detection by real-time quantitative polymerase chain reaction (PCR). The plasma was collected for IL-22 protein detection by enzyme-linked immunosorbent assay (ELISA).Results: The expression of AhR mRNA in PBMCs and IL-22 protein in plasma of patients with allergic asthma were higher than those in controlled asthma cases and healthy controls. The plasma concentrations of IL-22 had negative correlation with the predicted percentage of forced expiratory volume in the first second (FEV1%) and the percentage of FEV1 and forced vital capacity (FEV1/FVC%) and it was positively correlated with the asthma severity score (ASS) of the asthmatics. Conclusion: Our results suggested that both AhR and IL-22 might be involved in the pathogenesis of allergic asthma in human and the level of IL-22 might have some relationship with the severity of the disease.en_US
dc.identifier.citationZhu Jing, Cao Yong, Li Kaiyan, Wang Zhengyun, Zuo Peng, Xiong Weining, Xu Yongjian, xiong shengdao. Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma. Asian Pacific Journal of Allergy and Immunology, 2011 Sept; 29(3): 266-272.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/136423
dc.language.isoenen_US
dc.source.urihttps://apjai.digitaljournals.org/index.php/apjai/article/viewFile/356/457en_US
dc.subjectaryl hydrocarbon receptoren_US
dc.subjectinterleukin 22en_US
dc.subjectinterleukin 17en_US
dc.subjectT helper 17 cellen_US
dc.subjectallergic asthmaen_US
dc.titleIncreased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma.en_US
dc.typeArticleen_US
Files
Collections
Asian Pacific Journal of Allergy and Immunology