Autonomic status in systemic sclerosis in India.

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dc.contributor.authorYadav, Raj Kumaren_US
dc.contributor.authorGupta, Rajivaen_US
dc.contributor.authorThabah, Molly Maryen_US
dc.contributor.authorPoojary, Gopalen_US
dc.contributor.authorMadhavan, S Men_US
dc.contributor.authorDeepak, K Ken_US
dc.date.accessioned2006-10-04en_US
dc.date.accessioned2009-06-01T06:59:21Z
dc.date.available2006-10-04en_US
dc.date.available2009-06-01T06:59:21Z
dc.date.issued2006-10-04en_US
dc.description.abstractSystemic sclerosis (SSc) is a systemic connective tissue disease characterized by vasomotor disturbances. Autonomic dysfunction has been implicated in the pathogenesis of various symptoms in patients with SSc. In this retrospective study, thirty patients with SSc as cases and thirty age matched healthy subjects were enrolled as controls. The patients as well as controls were subjected to a standard battery of autonomic tests including reactivity and activity (tone) tests. Resting autonomic variables like blood pressure (BP), heart rate (HR) and respiratory rate (RR) were also recorded. In our study, we found significantly higher HR and RR in the patient group (P = 0.0001 and 0.012 respectively). We also observed significantly lower parasympathetic tone and parasympathetic reactivity in SSc patients than the controls. This study shows the status of autonomic functions in SSc patients in India, with lower central parasympathetic drive to the heart. The present study may give some insight for better understanding of this multisystem disorder of unknown etiology.en_US
dc.description.affiliationDepartment of Physiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationYadav RK, Gupta R, Thabah MM, Poojary G, Madhavan SM, Deepak KK. Autonomic status in systemic sclerosis in India. Indian Journal of Physiology and Pharmacology. 2006 Oct-Dec; 50(4): 397-402en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107810
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAutonomic Nervous System --physiopathologyen_US
dc.subject.meshBlood Pressure --physiologyen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHand Strength --physiologyen_US
dc.subject.meshHeart Rate --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshPressureen_US
dc.subject.meshRespiratory Mechanics --physiologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshScleroderma, Systemic --physiopathologyen_US
dc.subject.meshValsalva Maneuveren_US
dc.titleAutonomic status in systemic sclerosis in India.en_US
dc.typeJournal Articleen_US
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