Measurement of Arginase Activity in Erythrocytes in Newborns and Children and its Correlation with Plasma Ammonia Concentration

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dc.contributor.authorKousar, Uzmaen_US
dc.contributor.authorShetty, Prajna Pen_US
dc.contributor.authorK, Nalinien_US
dc.date.accessioned2020-04-10T01:54:48Z
dc.date.available2020-04-10T01:54:48Z
dc.date.issued2018-01
dc.description.abstractArginase is a urea cycle enzyme which catalyzes the cleavage of L-arginine to L-ornithine,and urea. Arginase deficiency is inherited as an autosomal recessive genetic disorder. Hyperammonemia refers to a condition with elevated levels of ammonia in the blood, which is a product of protein degradation. The lack of the arginase enzyme results in excessive accumulation of nitrogen, in the form of ammonia (hyperammonemia) and arginine (hyperargininemia) in the blood. In the present study, the erythrocyte arginase activity is measured along with plasma ammonia concentration in the newborns and children. The study group consists of 133 subjects which are divided into two groups based on the ammonia level. Group 1 consists of subjects with normal ammonia (n=92) and Group 2 consists of subjects with high ammonia (n=41). We found a significant decrease in arginase activity in the high ammonia group compared to the normal ammonia group. A significant negative correlation between arginase and ammonia is observed in both the groups. The result of this study suggests that arginase deficiency could be the cause for hyperammonemia in these cases. Hence, we suggest that estimation of erythrocyte arginase activity can be used as a screening procedure to detect arginase deficiency in newborns, infants, and children with hyperammonemiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal-576104, India.en_US
dc.identifier.citationKousar Uzma, Shetty Prajna P, K Nalini. Measurement of Arginase Activity in Erythrocytes in Newborns and Children and its Correlation with Plasma Ammonia Concentration. Indian Journal of Medical Sciences. 2018 JAN; 70(1): 15-17en_US
dc.identifier.issn0019-5359
dc.identifier.issn1998-3654
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196510
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber1en_US
dc.relation.volume70en_US
dc.source.urihttps://ijmsweb.com/view-pdf/?article=a56df5eba983fbad82bdd9af0b3ddc32/VOWtA==en_US
dc.subjectArginaseen_US
dc.subjecthyperammonemiaen_US
dc.subjecturea cycleen_US
dc.subjectnewborn screening.en_US
dc.titleMeasurement of Arginase Activity in Erythrocytes in Newborns and Children and its Correlation with Plasma Ammonia Concentrationen_US
dc.typeJournal Articleen_US
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