A comparative study of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in bipolar mania and schizophrenia

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dc.contributor.authorGoyal, MKen_US
dc.contributor.authorYadav, KSen_US
dc.contributor.authorSolanki, RKen_US
dc.date.accessioned2024-12-07T11:14:11Z
dc.date.available2024-12-07T11:14:11Z
dc.date.issued2024-01
dc.description.abstractObjectives: The role of immunological disturbance in bipolar disorder (BD) and schizophrenia has been highlighted by some studies. There are few studies available that compared the inflammatory markers between schizophrenia and BD, but only one study demonstrated the difference in terms of neutrophil/lymphocyte ratio (NLR) and Platelet/lymphocyte ratio (PLR) between them. So this study was conducted to compare the NLR and PLR values among schizophrenia, bipolar mania, and healthy controls in order to find out a potential biomarker for these disorders. Material and Methods: Eighty consecutive patients suffering from bipolar mania, 80 suffering from schizophrenia, and 80 healthy controls were recruited in the psychiatric center situated at a tertiary care hospital. Blood samples of all groups were transferred to the laboratory for complete blood count analysis. Thereafter, all the groups were compared by applying proper statistics. Results: Significant higher level of neutrophil count and NLR value was seen in both bipolar mania and schizophrenia groups compared to healthy controls. There was no difference observed between schizophrenia and the bipolar mania group regarding NLR, PLR, neutrophils, lymphocytes, and platelets values. Conclusion: NLR has appeared as a potential marker in our study, and it reflects a state of low-grade inflammation in both schizophrenia and bipolar mania. BD and schizophrenia have been considered as part of one continuum, which is also supported by the findings of our study. These markers can help in the prognosis and treatment of at least a subsection of patients and also are inexpensive and easy to assess.en_US
dc.identifier.affiliationsDepartment of Psychiatry, Sawai Man Singh (SMS) Medical College, Jaipuren_US
dc.identifier.affiliationsDepartment of Psychiatry, Employees State Insurance Corporation (ESIC)Model Hospital Jaipur, Sodala, Jaipur, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry, Sawai Man Singh (SMS) Medical Collegeen_US
dc.identifier.citationGoyal MK, Yadav KS, Solanki RK. A comparative study of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in bipolar mania and schizophrenia. Annals of the National Academy of Medical Sciences (India). 2024 Jan; 60(1): 20-25en_US
dc.identifier.issn0379-038X
dc.identifier.issn2454-5635
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/241072
dc.languageenen_US
dc.publisherNational Academy of Medical Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume60en_US
dc.source.urihttps://dx.doi.org/10.25259/ANAMS-2023-6-1-(941)en_US
dc.subjectNeutrophil/lymphocyte ratioen_US
dc.subjectPlatelet/lymphocyte ratioen_US
dc.subjectBipolar maniaen_US
dc.subjectSchizophreniaen_US
dc.titleA comparative study of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in bipolar mania and schizophreniaen_US
dc.typeJournal Articleen_US
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