Hemorrhagic fever in Cambodia is caused by dengue viruses: evidence for transmission of all four serotypes.

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dc.contributor.authorRathavuth, Hen_US
dc.contributor.authorVaughn, D Wen_US
dc.contributor.authorMinn, Ken_US
dc.contributor.authorNimmannitya, Sen_US
dc.contributor.authorNisalak, Aen_US
dc.contributor.authorRaengsakulrach, Ben_US
dc.contributor.authorRorabaugh, M Len_US
dc.contributor.authorYuvatha, Ken_US
dc.contributor.authorSophal, Oen_US
dc.date.accessioned2009-05-27T16:34:44Z
dc.date.available2009-05-27T16:34:44Z
dc.date.issued1997-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractHemorrhagic fever (HF) has been widespread in Cambodia and thought to be due to dengue virus although laboratory confirmation has been lacking. Between 1980 and 1995, 49,420 cases of HF and 3,032 deaths were reported. Cases increased during this period; large epidemics of HF occurred every two to three years. In 1995 there were 10,208 cases of HF with 424 deaths. Over a two day period in August 1995, 40 consecutive cases were investigated at the National Pediatric Hospital in Phnom Penh, Cambodia. All 40 cases were confirmed as dengue by virus identification and/or serology. Mean age was 6.5 years. Of 39 patients with complete medical records, the diagnoses were: dengue fever (n = 3), dengue hemorrhagic fever (DHF) grade 2 (n = 21), DHF grade 3 (n = 10), and DHF grade 4 (n = 5). The serologic response was secondary in 95%. Dengue virus was identified in 13 of 40 cases. All four dengue serotypes were identified. The high frequency of secondary infections, the low mean age of admission, and identification of all four dengue serotypes support the national statistics to show that DHF is highly endemic in Cambodia.en_US
dc.description.affiliationNational Pediatric Hospital, Phnom Penh, Cambodia.en_US
dc.identifier.citationRathavuth H, Vaughn DW, Minn K, Nimmannitya S, Nisalak A, Raengsakulrach B, Rorabaugh ML, Yuvatha K, Sophal O. Hemorrhagic fever in Cambodia is caused by dengue viruses: evidence for transmission of all four serotypes. The Southeast Asian Journal of Tropical Medicine and Public Health. 1997 Mar; 28(1): 120-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35533
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshCambodia --epidemiologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDengue Hemorrhagic Fever --mortalityen_US
dc.subject.meshDengue Virus --classificationen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshEndemic Diseasesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshSerotypingen_US
dc.subject.meshSurvival Analysisen_US
dc.titleHemorrhagic fever in Cambodia is caused by dengue viruses: evidence for transmission of all four serotypes.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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