Antimalarial and toxic effect of triple combination of pyronaridine, sulfadoxine and pyrimethamine.

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dc.contributor.authorShao, B Ren_US
dc.contributor.authorHuang, Z Sen_US
dc.contributor.authorShi, X Hen_US
dc.contributor.authorZhan, C Qen_US
dc.contributor.authorMeng, Fen_US
dc.contributor.authorYe, X Yen_US
dc.contributor.authorHuang, Jen_US
dc.contributor.authorHa, S Hen_US
dc.date.accessioned2009-05-27T14:42:33Z
dc.date.available2009-05-27T14:42:33Z
dc.date.issued1989-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe triple combination of pyronaridine, sulfadoxine and pyrimethamine which has been proven to be efficient in delaying emergence of drug resistance of rodent malarial parasites was further studied for potential application to malaria control. The antimalarial effect of the triple combination on Plasmodium berghei ANKA-infected mice and the toxic effects in mice and rats were additive. A single dose of pyronaridine 500 mg in combination with sulfadoxine, 1000 or 1500 mg, and pyrimethamine, 50 or 75 mg, given to 72 acute falciparum malaria patients resulted in a 100% cure rate with nil or mild side effects, and no recrudescence of asexual parasite over 4-week follow-up. Preliminary experiments on the drug effect on sporogony showed that the drug combination at the dose used could not completely interrupt the sporozoite formation although many retarded oocysts were found.en_US
dc.description.affiliationInstitute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.en_US
dc.identifier.citationShao BR, Huang ZS, Shi XH, Zhan CQ, Meng F, Ye XY, Huang J, Ha SH. Antimalarial and toxic effect of triple combination of pyronaridine, sulfadoxine and pyrimethamine. The Southeast Asian Journal of Tropical Medicine and Public Health. 1989 Jun; 20(2): 257-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30867
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimalarials --therapeutic useen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria --drug therapyen_US
dc.subject.meshMiceen_US
dc.subject.meshNaphthyridines --administration & dosageen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.subject.meshPyrimethamine --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshSulfadoxine --administration & dosageen_US
dc.subject.meshSulfanilamides --administration & dosageen_US
dc.titleAntimalarial and toxic effect of triple combination of pyronaridine, sulfadoxine and pyrimethamine.en_US
dc.typeJournal Articleen_US
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