Investigation of the haemolytic effects of Ancylostoma ceylanicum: observations on infected dogs in vivo and human and dog blood in vitro.

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dc.contributor.authorCarroll, S Men_US
dc.contributor.authorPryor, Jen_US
dc.contributor.authorKennett, D Wen_US
dc.contributor.authorGrove, D Ien_US
dc.date.accessioned2009-05-27T15:49:02Z
dc.date.available2009-05-27T15:49:02Z
dc.date.issued1984-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractInvestigations into the probable role of haemolysins in the causation of hookworm anaemia have been undertaken in living infected dogs. Secondly, the effects of living hookworms and various worm products on erythrocytes in vitro have been assessed. In dogs infected with varying numbers of A. ceylanicum, severe microcytic anaemia developed in the most heavily infected animals six weeks after infection. Erythrocytes from the latter animals showed significantly greater autohaemolysis in the presence of added glucose. When serum bilirubin and methaemalbumin, plasma haemoglobin, urinary urobilinogin and osmotic fragility of their red cells were measured, however, no evidence of haemolysis was detected. Erythrocytes from these animals appeared normal under scanning electron microscopy. In in vitro studies varying concentrations of adult worm extract had no effect on the haemolysis of either dog or human erythrocytes in the presence or absence of glucose nor on their mechanical fragility. There was no increase in 51Cr release from dog or human labelled red cells when incubated with either adult worm extract or excretory/secretory products of worms. Living adult worms caused an increase in 51Cr release from human but not dog labelled erythrocytes. Thus, the role of haemolysins in the genesis of hookworm anaemia is minimal.en_US
dc.identifier.citationCarroll SM, Pryor J, Kennett DW, Grove DI. Investigation of the haemolytic effects of Ancylostoma ceylanicum: observations on infected dogs in vivo and human and dog blood in vitro. The Southeast Asian Journal of Tropical Medicine and Public Health. 1984 Mar; 15(1): 129-34en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33732
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAncylostoma --physiologyen_US
dc.subject.meshAncylostomiasis --blooden_US
dc.subject.meshAnemia, Hemolytic --blooden_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshErythrocytes --drug effectsen_US
dc.subject.meshHemolysisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshOsmotic Fragilityen_US
dc.subject.meshTissue Extracts --pharmacologyen_US
dc.titleInvestigation of the haemolytic effects of Ancylostoma ceylanicum: observations on infected dogs in vivo and human and dog blood in vitro.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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