The immunohistochemical expression of c-MET and RON in lung adenocarcinoma with clinicopathologic correlation

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dc.contributor.authorKim, YAen_US
dc.contributor.authorSung, WJen_US
dc.date.accessioned2025-06-19T05:55:12Z
dc.date.available2025-06-19T05:55:12Z
dc.date.issued2025-03
dc.description.abstractBackground: Mesenchymal epidermal transition (MET) and receptor originating from nantes (RON) are transmembrane tyrosine kinase receptors. Both are members of a proto?oncogene family and thus play a role in the pathogenesis of various cancers and acquired resistance to kinase inhibitors in lung cancer. Aims: The aim of this study was to investigate the immunohistochemical expression of c?MET and RON in lung adenocarcinoma and its clinicopathologic correlation. Settings and Design: Retrospective study. Materials and Methods: The immunohistochemical c?MET and RON expression in specimens obtained from lung adenocarcinoma (n = 175) and associated clinicopathologic parameters were evaluated. Statistical Analysis Used: The correlation between c?MET and RON expression was analyzed by Chi?square test. A Cox proportional hazards model and Kaplan?Meier curve analysis were used to evaluate the risk factors and prognosis. Results: High expression of the c?MET protein showed a strong correlation with that of RON (P = 0.013, kappa = 0.183). Five?year survival and recurrence?free 5?year survival were not associated with high expression of c?MET or RON. High c?MET expression was significantly associated with age older than 60 years (P = 0.000), tumor differentiation (P = 0.009), lymphovascular invasion (P = 0.016), and pleural invasion (P = 0.005). High RON expression was associated with a solid growth pattern (P = 0.001) and pleural invasion (P = 0.002). Conclusions: The results point to the potential of immunohistochemical expression of c?MET and RON as useful prognostic markers of unfavorable histopathologic features in lung adenocarcinoma.en_US
dc.identifier.affiliationsDepartment of Pathology, Daegu Catholic University School of Medicine, Duryugongwon?ro 17?gil 33, Nam?gu, Daegu 42472; Seoul Clinical Laboratories of Daegu, 95, Hwarang?ro, Dong?gu, Daegu, 41238, Republic of Koreaen_US
dc.identifier.affiliationsDepartment of Pathology, Daegu Catholic University School of Medicine, Duryugongwon?ro 17?gil 33, Nam?gu, Daegu 42472en_US
dc.identifier.citationKim YA, Sung WJ. The immunohistochemical expression of c-MET and RON in lung adenocarcinoma with clinicopathologic correlation. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 23-29en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249957
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume68en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_358_22en_US
dc.subjectc?METen_US
dc.subjectlung adenocarcinomaen_US
dc.subjectnon?small cell lung canceren_US
dc.subjectRONen_US
dc.titleThe immunohistochemical expression of c-MET and RON in lung adenocarcinoma with clinicopathologic correlationen_US
dc.typeJournal Articleen_US
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