Effects of Nebulized Dexamethasone Versus Nebulized Ketamine on the Attenuation of Post-operative Sore Throat Following Endotracheal Intubation

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dc.contributor.authorKumari, Saladi Arunaen_US
dc.contributor.authorBhashyam, Snehalathaen_US
dc.contributor.authorLakshmi, B Sowbhagyaen_US
dc.date.accessioned2020-10-16T08:38:14Z
dc.date.available2020-10-16T08:38:14Z
dc.date.issued2019-12
dc.description.abstractBackground: General anesthesia (GA) with endotracheal intubation is a frequent cause of airway mucosal trauma whichresults in the post-operative sore throat (POST), with an incidence of 21–65%. Although minor and self-limiting complication,it produces significant discomfort and annoyance to the patient. This study was aimed to compare the efficacy of nebulizeddexamethasone versus ketamine in preventing POST.Materials and Methods: After approval from the institutional ethics committee and written informed consent, 100 patients ofthe American Society of Anesthesiologists physical status 1–2, aged between 20 and 60 years of either sex, undergoing GAwith endotracheal intubation were included in this prospective, randomized, and double-blind study. Patients were randomizedinto two groups of 50 each (n = 50); Group D: Patients received dexamethasone 8 mg (2 ml) with 3 ml of normal saline (totalvolume of 5 ml) for nebulization and Group K: Patients received ketamine (preservative free) 50 mg (1 ml) with 4 ml of normalsaline (total volume of 5 ml) for nebulization. After 15 min of nebulization, induction was done, POST assessment was done at0, 2, 4, 6, 12, and 24 h post-extubation. The severity of POST was graded on a 4-point scale (0–3).Results: The total incidence of POST was 19% in this study. Five patients (10%) in dexamethasone group and 14 patients(28%) in ketamine group experienced POST (Fisher’s exact test, P = 0.039). Reduction in the incidence and severity of POSTin the dexamethasone group when compared to ketamine group at 2, 4, 6, and 12 h postoperatively is statistically significant(P < 0.05*).Conclusion: Pre-operative single dose of nebulized dexamethasone 8 mg effectively attenuates POST in patients followingGA with endotracheal intubation compared to nebulized ketamine 50 mg without any detrimental effects.en_US
dc.identifier.affiliationsAssistant Professor, Department of Anesthesiology and Critical Care, Rangaraya Medical College, Kakinada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Anesthesiology and Critical Care, Rangaraya Medical College, Kakinada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsProfessor and HOD, Department of Anesthesiology and Critical Care, Rangaraya Medical College, Kakinada, Andhra Pradesh, Indiaen_US
dc.identifier.citationKumari Saladi Aruna, Bhashyam Snehalatha, Lakshmi B Sowbhagya. Effects of Nebulized Dexamethasone Versus Nebulized Ketamine on the Attenuation of Post-operative Sore Throat Following Endotracheal Intubation. International Journal of Scientific Study. 2019 Dec; 7(9): 10-15en_US
dc.identifier.issn2321-595X
dc.identifier.issn2321-6354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209232
dc.languageenen_US
dc.publisherInternational Research Organization for Life & Health Sciences (IROLHS)en_US
dc.relation.issuenumber9en_US
dc.relation.volume7en_US
dc.source.urihttps://www.ijss-sn.com/uploads/2/0/1/5/20153321/03_ijss_dec_oa03_-_2019.pdfen_US
dc.subjectDexamethasoneen_US
dc.subjectGeneral anesthesiaen_US
dc.subjectIntubationen_US
dc.subjectKetamineen_US
dc.subjectNebulizationen_US
dc.subjectSore throaten_US
dc.titleEffects of Nebulized Dexamethasone Versus Nebulized Ketamine on the Attenuation of Post-operative Sore Throat Following Endotracheal Intubationen_US
dc.typeJournal Articleen_US
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