Anti-inflammatory action of steroid inhalers.

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dc.contributor.authorTaskar, V Sen_US
dc.contributor.authorMahashur, A Aen_US
dc.contributor.authorJohn, P Jen_US
dc.contributor.authorKolhatkar, V Pen_US
dc.contributor.authorMenon, Len_US
dc.contributor.authorBijur, Sen_US
dc.date.accessioned1993-05-01en_US
dc.date.accessioned2009-05-30T17:33:45Z
dc.date.available1993-05-01en_US
dc.date.available2009-05-30T17:33:45Z
dc.date.issued1993-05-01en_US
dc.description.abstractWith mucosal inflammation contributing to the pathogenesis of asthma, it is increasingly accepted that long term steroid inhalers may induce remission in chronic long standing asthmatics. The present study involved 44 stable asthmatics who were randomly given either beclomethasone dipropionate inhaler (50 ug) 2 puffs qds or salbutamol inhaler (100 mcg) 2 puffs tds in addition to their oral bronchodilators. Pulmonary function testing, bronchoalveolar lavage and complete blood count were done at basal and weekly intervals and at the end of the study. The absolute eosinophil count showed a significant drop in the beclomethasone group as compared to the salbutamol group. Serial lung functions showed a significant improvement in the pre-bronchodilator PEFR and the pre-bronchodilator FVC in the beclomethasone group as compared to the salbutamol group. There was no significant change in the lavage eosinophil count pre and post-bronchodilator in both groups. Steroid inhalers are thus useful in long term management of bronchial asthma especially with respect to reducing bronchodilator requirement.en_US
dc.description.affiliationDept of Chest Medicine and Pathology, KEM Hospital, Bombay.en_US
dc.identifier.citationTaskar VS, Mahashur AA, John PJ, Kolhatkar VP, Menon L, Bijur S. Anti-inflammatory action of steroid inhalers. Journal of the Association of Physicians of India. 1993 May; 41(5): 281-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/85006
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAdulten_US
dc.subject.meshAlbuterol --administration & dosageen_US
dc.subject.meshAsthma --drug therapyen_US
dc.subject.meshBeclomethasone --administration & dosageen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleAnti-inflammatory action of steroid inhalers.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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