Gastrointestinal stromal tumor: Analysis of outcome and correlation with c-kit status in Indian population.

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dc.contributor.authorCyriac, S
dc.contributor.authorRajendranath, R
dc.contributor.authorSagar, T G
dc.date.accessioned2014-12-29T10:28:28Z
dc.date.available2014-12-29T10:28:28Z
dc.date.issued2014-01
dc.description.abstractAIMS: The aim of the present study is to analyse the outcome and genotypic pattern of metastatic GIST patients which is largely unknown in India. MATERIALS AND METHODS: The present study was a retrospective analysis of 24 patients of metastatic GIST. The case records were analysed for clinical profile, treatment response and prognostic factors. The archival samples were retrieved for c‑kit mutation analysis in all but 5 patients for mutation analysis. RESULTS: The median age of the study population was 56 years. At a median follow up of 29 months, the PFS was 45% at 2 years. Activating c‑kit mutations were detected in 10 cases (52.6%). 80% of the mutations were located in Exon 11. CONCLUSIONS: The outcome of metastatic GIST patients has definitely improved from a virtually incurable state to a disease where median OS has reached 60 months. The genotype of Indian patients with GIST may be different from the western population which needs to be confirmed in a larger study.en_US
dc.identifier.citationCyriac S, Rajendranath R, Sagar T G. Gastrointestinal stromal tumor: Analysis of outcome and correlation with c-kit status in Indian population. Indian Journal of Cancer. 2014 Jan-Mar; 51(1): 35-39.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154281
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2014;volume=51;issue=1;spage=35;epage=39;aulast=Cyriacen_US
dc.subjectGastrointestinal stromal tumoren_US
dc.subjectImatiniben_US
dc.subjectc‑kiten_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshDNA Mutational Analysis
dc.subject.meshExons --genetics
dc.subject.meshFemale
dc.subject.meshFollow Up Studies
dc.subject.meshGastrointestinal Stromal Tumors --epidemiology
dc.subject.meshGastrointestinal Stromal Tumors --genetics
dc.subject.meshGastrointestinal Stromal Tumors --mortality
dc.subject.meshGastrointestinal Stromal Tumors --pathology
dc.subject.meshGenotypes
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshLiver Neoplasms --epidemiology
dc.subject.meshLiver Neoplasms --genetics
dc.subject.meshLiver Neoplasms --mortality
dc.subject.meshLiver Neoplasms --secondary
dc.subject.meshLung Neoplasms --epidemiology
dc.subject.meshLung Neoplasms --genetics
dc.subject.meshLung Neoplasms --mortality
dc.subject.meshLung Neoplasms --secondary
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMutation --genetics
dc.subject.meshNeoplasm Staging
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshPrognosis
dc.subject.meshProto-Oncogene Proteins c-kit
dc.subject.meshRetrospective Studies
dc.subject.meshSurvival Rate
dc.titleGastrointestinal stromal tumor: Analysis of outcome and correlation with c-kit status in Indian population.en_US
dc.typeArticleen_US
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