A case–control study of the ocular surface and tear film parameters in gestational diabetes mellitus

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dc.contributor.authorSingh, Chaithanya Ben_US
dc.contributor.authorSavur, Sheetal Aen_US
dc.date.accessioned2023-08-25T06:36:42Z
dc.date.available2023-08-25T06:36:42Z
dc.date.issued2023-04
dc.description.abstractPurpose: Gestational diabetes mellitus (GDM) is fairly common in India. There is an interplay of various factors like androgens, sex hormone?binding globulin (SHBG), estrogen, and progesterone on the tear film in pregnancy. Diabetes mellitus in itself affects the lacrimal function unit (LFU) and ocular surface. This study was therefore performed to assess the effect of the various factors on the tear film function and ocular surface in GDM using different diagnostic tests. Methods: Case–control study includes 49 subjects after calculating the sample size. Cases of newly diagnosed GDM in their second or third trimester of pregnancy without any ocular or systemic comorbidities. The following standard tests were performed, namely, ocular surface disease index (OSDI) scoring, Schirmer’s test, tear film breakup time (TBUT), and ocular surface staining (SICCA). Results: The two study groups did not differ significantly in terms of age, gestational age, and presenting symptoms. None of the patients had diabetic retinopathy, and the ocular surface was unaffected in both groups. There was a significant difference in the Schirmer’s II test (P = 0.01) between the groups, while Schirmer’s I (P = 0.06) and TBUT (P = 0.07) were not significant. Conclusion: Our study suggests that GDM patients can potentially suffer from DES despite the lack of symptoms and may be the basis for conducting larger studies to justify routine screening of GDM for DES in order to improve the quality of life of pregnant womenen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Yenepoya Medical College, Mangalore, Karnataka, Indiaen_US
dc.identifier.citationSingh Chaithanya B, Savur Sheetal A. A case–control study of the ocular surface and tear film parameters in gestational diabetes mellitus. Indian Journal of Ophthalmology. 2023 Apr; 71(4): 1459-1462en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224947
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber4en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_2663_22en_US
dc.subjectDry eyeen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectpregnancyen_US
dc.titleA case–control study of the ocular surface and tear film parameters in gestational diabetes mellitusen_US
dc.typeJournal Articleen_US
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