Evaluation of Mast Cell Profile in the Skin Lesions of Leprosy

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dc.contributor.authorMohiten_US
dc.contributor.authorDixit, Sachien_US
dc.contributor.authorSharma, Rachnaen_US
dc.contributor.authorSharma, Preetien_US
dc.contributor.authorKumar, Pradeepen_US
dc.date.accessioned2019-12-06T09:24:07Z
dc.date.available2019-12-06T09:24:07Z
dc.date.issued2018-11
dc.description.abstractBackground: Aim of the present study was to evaluate the role of Mast cells in the Histo-Pathogenesis of Leprosy by assessing incidence of various Histo-Pathological types of Leprosy, Correlating of Mast cell profile (Mast cell Density & Morphology) in different Histological types of Leprosy lesions, by correlating with Reactional & Non-Reactional groups of Leprosy cases and by correlation of Mast cell profile in doubtful cases as in Indeterminate type. Lepromatous Leprosy was observed in higher age group as compared to Tuberculoid leprosy. Mast Cell Density was found increasing from Polar Tuberculoid to Polar Lepromatous spectrum of disease. In every type of Leprosy, mast Cell Density was reduced significantly in the Reactional Group as compared to Non-Reactional Group. The aim of the present study was to evaluate the role of Mast cells in the Histo-Pathogenesis of Leprosy by assessing incidence of various Histo-Pathological types of Leprosy. Methods: A cross sectional, observational study was conducted among 200.Correlation of mast cell profile (Mast cell Density & Morphology) in different Histological types of Leprosy lesions was done, by correlating with Reactional & Non-Reactional groups of Leprosy cases and by correlation of Mast cell profile in doubtful cases as in Indeterminate type. Lepromatous Leprosy was observed in higher age group as compared to Tuberculoid leprosy. Results: Mast Cell Density was found Increasing from Polar Tuberculoid to Polar Lepromatous spectrum of disease. In every type of Leprosy, mast Cell Density was reduced significantly in the Reactional Group as compared to Non-Reactional Group. Conclusion: Larger such studies of Leprosy employing special staining methods viz. pH dependent Toluidine Blue staining, studies employing Immuno-Fluorescence on Tissue biopsy specimens, as well as studies on experimental animals, to help us achieve a better understanding of the pathogenesis, outcome and prognosis of Leprosy.en_US
dc.identifier.affiliationsMedical University of Americas, Department of Pathology, Potwork Estate, Nevis, St. Kitts and Nevis KN1101en_US
dc.identifier.affiliationsSeva Hospital and Research Centre, Sitapur Road, Lucknow, UP, Indiaen_US
dc.identifier.affiliationsTSM Medical College and Hospital, Lucknow, UP, Indiaen_US
dc.identifier.affiliationsSantosh Medical College and Hospital, Ghaziabad, UP, Indiaen_US
dc.identifier.affiliationsSantosh Medical College and Hospital, Ghaziabad, UP, Indiaen_US
dc.identifier.citationMohit, Dixit Sachi, Sharma Rachna, Sharma Preeti, Kumar Pradeep. Evaluation of Mast Cell Profile in the Skin Lesions of Leprosy. Annals of International medical and Dental Research. 2018 Nov; 4(11): 4-8en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188440
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber11en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.21276/aimdr.2018.4.6.PT2en_US
dc.titleEvaluation of Mast Cell Profile in the Skin Lesions of Leprosyen_US
dc.typeJournal Articleen_US
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