Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais.

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dc.contributor.authorChanprasertyothin, Sen_US
dc.contributor.authorOngphiphadhanakul, Ben_US
dc.contributor.authorRajatanavin, Ren_US
dc.contributor.authorPiaseu, Nen_US
dc.contributor.authorChailurkit, L Oen_US
dc.contributor.authorPuavilai, Gen_US
dc.date.accessioned2009-05-27T18:30:59Z
dc.date.available2009-05-27T18:30:59Z
dc.date.issued2000-10-06en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThis study determined the genotype distribution of apolipoprotein E (apo E) gene and its relation to serum lipids in 217 healthy Thais consisting of 79 males and 138 females. Serum total cholesterol (TC), HDL-cholesterol (HDL-C) and triglyceride (TG) concentrations were determined by enzymatic-colorimetric methods, while serum LDL-cholesterol (LDL-C) levels were calculated using Friedewald formula. Apo E genotypes were determined by PCR-RFLP. Out of 217 subjects, apo E genotype frequencies were 5.5 per cent for E2/E2, 12.4 per cent for E2/E3, 81.1 per cent for E3/E3 and 0.9 per cent for E4/E4. In men, advancing age was associated with increased serum TC (r = 0.28, P < 0.05) and LDL-C (r = 0.27, P < 0.01). Subjects having the E2 allele had lower TC (r = -0.27, P < 0.05) and LDL-C. (r = -0.25, P < 0.05). Age and apo E genotypes were not associated with HDL-C and TG in men. In women, increasing age was related to higher serum TC (r = 0.45, P < 0.001), LDL-C (r = 0.44, P < 0.001), TG (r = 0.40, P < 0.001) and lower HDL-C (r = -0.36, P < 0.001). The presence of E2 allele was related to lower TC (r = -0.24, P < 0.001), LDL-C (r = -0.26, P < 0.001), TG (r = -0.15, P < 0.05) and higher HDL-C (r = 0.20, P < 0.01) independent of age and menopausal status. We concluded that the epsilon 4 allele of apo E gene is rare in Thais. The presence of the epsilon 2 allele is associated with a more favorable lipid profile and there is a sexual dimorphism concerning the effect of apo E genotype on serum HDL-C and TG.en_US
dc.description.affiliationResearch Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.en_US
dc.identifier.citationChanprasertyothin S, Ongphiphadhanakul B, Rajatanavin R, Piaseu N, Chailurkit LO, Puavilai G. Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais. Journal of the Medical Association of Thailand. 2000 Oct; 83(10): 1233-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39303
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshApolipoproteins E --analysisen_US
dc.subject.meshCholesterol, HDL --blooden_US
dc.subject.meshCholesterol, LDL --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshThailanden_US
dc.subject.meshTriglycerides --blooden_US
dc.titleCorrelation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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