Diagnosis & treatment of tuberculosis in HIV co-infected patients.

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dc.contributor.authorPadmapriyadarsini, C
dc.contributor.authorNarendran, G
dc.contributor.authorSwaminathan, Soumya
dc.date.accessioned2012-03-27T09:07:43Z
dc.date.available2012-03-27T09:07:43Z
dc.date.issued2011-12
dc.description.abstractHuman immunodeficiency virus (HIV) associated tuberculosis (TB) remains a major global public health challenge, with an estimated 1.4 million patients worldwide. Co-infection with HIV leads to challenges in both the diagnosis and treatment of tuberculosis. Further, there has been an increase in rates of drug resistant tuberculosis, including multi-drug (MDR-TB) and extensively drug resistant TB (XDRTB), which are difficult to treat and contribute to increased mortality. Because of the poor performance of sputum smear microscopy in HIV-infected patients, newer diagnostic tests are urgently required that are not only sensitive and specific but easy to use in remote and resource-constrained settings. The treatment of co-infected patients requires antituberculosis and antiretroviral drugs to be administered concomitantly; challenges include pill burden and patient compliance, drug interactions, overlapping toxic effects, and immune reconstitution inflammatory syndrome. Also important questions about the duration and schedule of anti-TB drug regimens and timing of antiretroviral therapy remain unanswered. From a programmatic point of view, screening of all HIV-infected persons for TB and viceversa requires good co-ordination and communication between the TB and AIDS control programmes. Linkage of co-infected patients to antiretroviral treatment centres is critical if early mortality is to be prevented. We present here an overview of existing diagnostic strategies, new tests in the pipeline and recommendations for treatment of patients with HIV-TB dual infection.en_US
dc.identifier.citationPadmapriyadarsini C, Narendran G, Swaminathan Soumya. Diagnosis & treatment of tuberculosis in HIV co-infected patients. Indian Journal of Medical Research. 2011 Dec; 134(6): 850-865.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/137346
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284094/en_US
dc.subjectCo-infectionen_US
dc.subjectdiagnosisen_US
dc.subjectdrug resistanceen_US
dc.subjectHIVen_US
dc.subjectIRISen_US
dc.subjecttreatmenten_US
dc.subjecttuberculosisen_US
dc.subject.meshAntiretroviral Therapy, Highly Active --adverse effects
dc.subject.meshAntiretroviral Therapy, Highly Active --methods
dc.subject.meshCoinfection --drug therapy
dc.subject.meshCoinfection --prevention & control
dc.subject.meshDiagnostic Techniques, Respiratory System
dc.subject.meshDrug Administration Schedule
dc.subject.meshDrug Interactions
dc.subject.meshHIV Infections --complications
dc.subject.meshHumans
dc.subject.meshImmune Reconstitution Inflammatory Syndrome --etiology
dc.subject.meshPatient Compliance
dc.subject.meshPublic Health Practice
dc.subject.meshSerologic Tests --methods
dc.subject.meshTuberculosis --complications
dc.subject.meshTuberculosis --diagnosis
dc.subject.meshTuberculosis --drug therapy
dc.subject.meshTuberculosis --prevention & control
dc.titleDiagnosis & treatment of tuberculosis in HIV co-infected patients.en_US
dc.typeArticleen_US
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