Indian studies on genetic polymorphisms and cancer risk.

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dc.contributor.authorBag, A
dc.contributor.authorJyala, N S
dc.contributor.authorBag, N
dc.date.accessioned2013-01-21T10:41:01Z
dc.date.available2013-01-21T10:41:01Z
dc.date.issued2012-01
dc.description.abstractGenetic influences on cancer development have been extensively investigated during the last decade following publication of human genome sequence. The present review summarizes case-control studies on genetic polymorphisms and cancer risk in Indians. It is observed that the most commonly studied genes in the Indian population included members of phase I and phase II metabolic enzymes. Other than these genes, genetic polymorphisms for cell cycle and apoptosis-related factors, DNA repair enzymes, immune response elements, growth factors, folate metabolizing enzymes, vitamin/hormone receptors, etc., were investigated. Several studies also evidenced a stronger risk for combined genotypes rather than a single polymorphism. Gene-environment interaction was also found to be a determining factor for cancer development in some experiments. Data for single polymorphism and single cancer type, however, was insufficient to validate an association. It appears that much more experiments involving larger sample size, cross-tabulating genetic polymorphisms and environmental factors are required in order to identify genetic markers for different cancers in Indian populations.en_US
dc.identifier.citationBag A, Jyala N S, Bag N. Indian studies on genetic polymorphisms and cancer risk. Indian Journal of Cancer. 2012 Jan-Mar; 49(1): 144-162.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144565
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2012;volume=49;issue=1;spage=144;epage=162;aulast=Bagen_US
dc.subjectCancer associationen_US
dc.subjectcombined genotypeen_US
dc.subjectgene-environment interactionen_US
dc.subjectIndian populationen_US
dc.subjectpolymorphismsen_US
dc.subject.meshCell Cycle Proteins --genetics
dc.subject.meshDNA Repair Enzymes --genetics
dc.subject.meshGenes, MHC Class II
dc.subject.meshGenetic Association Studies
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshIntercellular Signaling Peptides and Proteins --genetics
dc.subject.meshMetabolic Detoxication, Phase I --genetics
dc.subject.meshMetabolic Detoxication, Phase II --genetics
dc.subject.meshNeoplasms --genetics
dc.subject.meshPolymorphism, Genetic
dc.titleIndian studies on genetic polymorphisms and cancer risk.en_US
dc.typeArticleen_US
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