Effect of medroxyprogesterone acetate on hepatic lipid profile of female rats under various states of nutrition.

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dc.contributor.authorMalik, Ven_US
dc.contributor.authorMajumdar, Sen_US
dc.contributor.authorSingh, Ren_US
dc.contributor.authorVohra, Ren_US
dc.contributor.authorNagpaul, J Pen_US
dc.date.accessioned1983-10-01en_US
dc.date.accessioned2009-06-01T07:26:06Z
dc.date.available1983-10-01en_US
dc.date.available2009-06-01T07:26:06Z
dc.date.issued1983-10-01en_US
dc.description.abstractThe effect of medroxyprogesterone acetate (MPA) treatment on hepatic lipid profile was studied in female rats kept on protein-deficient diet, on normal restricted diet and on normal, ad libitum diet. A significant decline in total and free cholesterol levels was observed in rats kept on protein-deficient diet and on normal, restricted diet. However, protein-deficient animals exhibited a significant rise in the liver triglyceride level. In rats on normal, ad libitum diet only, MPA treatment resulted in elevated levels of triglycerides and increased esterification of cholesterol. This was mostly due to increased incorporation of acetate into esterified cholesterol and triglyceride as evident from studies using the labelled precursor. Total phospholipid content was found to be unaffected by MPA in all the groups suggesting that the drug and dietary protein level have no effect on hepatic phospholipid content.en_US
dc.identifier.citationMalik V, Majumdar S, Singh R, Vohra R, Nagpaul JP. Effect of medroxyprogesterone acetate on hepatic lipid profile of female rats under various states of nutrition. Indian Journal of Physiology and Pharmacology. 1983 Oct-Dec; 27(4): 323-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108152
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarbon Radioisotopesen_US
dc.subject.meshCholesterol --metabolismen_US
dc.subject.meshDietary Proteins --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshMedroxyprogesterone --pharmacologyen_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTriglycerides --metabolismen_US
dc.titleEffect of medroxyprogesterone acetate on hepatic lipid profile of female rats under various states of nutrition.en_US
dc.typeJournal Articleen_US
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