Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation.

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dc.contributor.authorCinici, Emine
dc.contributor.authorAhiskali, Ibrahim
dc.contributor.authorCetin, Nihal
dc.contributor.authorSuleyman, Bahadir
dc.contributor.authorKukula, Osman
dc.contributor.authorAltuner, Durdu
dc.contributor.authorCoban, Abdulkadir
dc.contributor.authorBalta, Hilal
dc.contributor.authorKuzucu, Mehmet
dc.contributor.authorSuleyman, Halis
dc.date.accessioned2016-12-05T07:04:17Z
dc.date.available2016-12-05T07:04:17Z
dc.date.issued2016-06
dc.description.abstractPurpose: Information is lacking on the protective effects of thiamine pyrophosphate (TPP) against hyperglycemia‑induced retinopathy in rats. This study investigated the biochemical and histopathological aspects of the effect of TPP on hyperglycemia‑induced retinopathy induced by alloxan in rats. Materials and Methods: The rats were separated into a diabetic TPP‑administered group (DTPG), a diabetes control group (DCG) and a healthy group (HG). While the DTPG was given TPP, the DCG and HG were administered distilled water as a solvent at the same concentrations. This procedure was repeated daily for 3 months. At the end of this period, all of the rats were euthanized under thiopental sodium anesthesia, and biochemical and histopathological analyses of the ocular retinal tissues were performed. The results of the DTPG were compared with those of the DCG and HG. Results: TPP prevented hyperglycemia by increasing the amount of malondialdehyde and decreasing endogen antioxidants, including total glutathione, glutathione reductase, glutathione S‑transferase and superoxide dismutase. In addition, the amounts of the DNA oxidation product 8‑hydroxyguanine were significantly lower in the retinas of the DTPG compared to the DCG. In the retinas of the DCG, there was a marked increase in vascular structures and congestion, in addition to edema. In contrast, little vascularization and edema were observed in the DTPG, and there was no congestion. The results suggest that TPP significantly reduced the degree of hyperglycemia‑induced retinopathy. Conclusions: The results of this study indicate that TPP may be useful for prophylaxis against diabetic retinopathy.en_US
dc.identifier.citationCinici Emine, Ahiskali Ibrahim, Cetin Nihal, Suleyman Bahadir, Kukula Osman, Altuner Durdu, Coban Abdulkadir, Balta Hilal, Kuzucu Mehmet, Suleyman Halis. Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation. Indian Journal of Ophthalmology. 2016 June; 64(6): 434-439.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/179310
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991169/en_US
dc.subjectAlloxanen_US
dc.subjectantioxidantsen_US
dc.subjectdiabetic retinopathyen_US
dc.subjectoxidantsen_US
dc.subjectraten_US
dc.subjectthiamineen_US
dc.titleEffect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation.en_US
dc.typeArticleen_US
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