Effects of Prenatal Arsenic Exposure Via Maternal Blood on Placental GLI3 Expression and Neonatal Outcomes

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dc.contributor.authorSingh, Sen_US
dc.contributor.authorAdhikary, Jen_US
dc.contributor.authorBiswas, Sen_US
dc.contributor.authorBiswas, SCen_US
dc.date.accessioned2025-08-13T09:54:24Z
dc.date.available2025-08-13T09:54:24Z
dc.date.issued2025-03
dc.description.abstractBackground: Prenatal arsenic exposure can harm both the mother and foetus by changing gene expression and impacting foetal growth. The study aimed to assess the impact of arsenic exposure on GLI3 expression in feto-placental tissue via maternal blood and record neonatal outcomes. Material and Methods: The study used 54 mother-infant pairs. Atomic absorption spectrophotometer used for measuring arsenic in maternal blood. Based on the median value of arsenic content in maternal blood, samples were split into two groups: the arsenic-low and the arsenic-high group. Maternal age, gestational age, arsenic exposure history, neonatal data were compared between two groups. Using qRT-PCR fold change in GLI3 expression was determined. Results: Many participants resided in arsenic-contaminated regions and consumed underground water. The arsenic high group had a considerably higher mean arsenic content. The arsenic high group had a considerably lower gestational age than the low group. Neonatal birth weight significantly reduced in arsenic high group. Neonatal birth length increased in arsenic high group in comparison to arsenic-low group. Exposure to arsenic significantly decreased the relative expression of GLI3. Conclusion: Prenatal arsenic exposure via maternal blood reduces GLI3 expression and affects neonatal anthropometry.en_US
dc.identifier.affiliationsInstitute of Post Graduate Medical Education and Research, Kolkata, Indiaen_US
dc.identifier.affiliationsPresidency University, Kolkata, Indiaen_US
dc.identifier.affiliationsNorth City Diagnostic and Research Centre, Kolkata, Indiaen_US
dc.identifier.affiliationsInstitute of Post Graduate Medical Education and Research, Kolkata, Indiaen_US
dc.identifier.citationSingh S, Adhikary J, Biswas S, Biswas SC. Effects of Prenatal Arsenic Exposure Via Maternal Blood on Placental GLI3 Expression and Neonatal Outcomes. National Journal of Medical Research . 2025 Mar; 15(1): 21-26en_US
dc.identifier.issn2249-4995
dc.identifier.issn2277-8810
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252799
dc.languageenen_US
dc.publisherMedsci Publicationsen_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.55489/njmr.150120251032en_US
dc.subjectArsenicen_US
dc.subjectPregnancyen_US
dc.subjectMaternal Healthen_US
dc.subjectGLI3en_US
dc.subjectFetusen_US
dc.subjectNeonatal Outcomeen_US
dc.titleEffects of Prenatal Arsenic Exposure Via Maternal Blood on Placental GLI3 Expression and Neonatal Outcomesen_US
dc.typeJournal Articleen_US
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