Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis

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dc.contributor.authorYang, Xen_US
dc.contributor.authorFeng, H.en_US
dc.date.accessioned2023-08-10T07:33:18Z
dc.date.available2023-08-10T07:33:18Z
dc.date.issued2023-06
dc.description.abstractBackground and Aims: The host immune system plays an important role in the pathogenesis and defense mechanism of Mycobacterium tuberculosis (Mtb). This study aimed to explore the different changes in the immune system between smear-negative pulmonary tuberculosis (PTB) and smear-positive PTB patients. Materials and Methods: A total of 85 active PTB patients and 50 healthy adults were enrolled. The participants were divided into smear-negative PTB, smear-positive PTB, and control groups. Chest computed tomography (CT) and lymphocyte subgroup counts in peripheral blood were measured in all participants. Results: There were higher numbers of CD4 + T-cells, NK cells, and pulmonary cavities in the smear-positive PTB group, whereas the numbers of B-ells were significantly increased in the smear-negative PTB group. Conclusions: Smear-negative PTB showed fewer pulmonary cavities, mild inflammatory response, lower numbers of immune cells, and higher numbers of B- cells.en_US
dc.identifier.affiliationsInfectious Diseases Section, Nanjing Jiangbei Hospital, Nanjing, Chinaen_US
dc.identifier.affiliationsInfectious Diseases Section, Nanjing Jiangbei Hospital; Infectious Diseases Section, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, Chinaen_US
dc.identifier.citationYang X, Feng H.. Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis. Indian Journal of Pathology & Microbiology. 2023 Jun; 66(2): 321-326en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223439
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume66en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_72_21en_US
dc.subjectLymphocyte subsetsen_US
dc.subjectmycobacterium tuberculosisen_US
dc.subjectpulmonary tuberculosisen_US
dc.subjectsmear-negativeen_US
dc.subjectsmear-positiveen_US
dc.titleChanges of lymphocyte subsets in smear-negative pulmonary tuberculosisen_US
dc.typeJournal Articleen_US
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