Promising sponge derived marine fungi as antibacterial and biofilm inhibitors

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dc.contributor.authorWigati, Den_US
dc.contributor.authorSetyowati, EPen_US
dc.contributor.authorPratiwi, SUTen_US
dc.contributor.authorNugraha, ASen_US
dc.date.accessioned2024-11-30T11:20:31Z
dc.date.available2024-11-30T11:20:31Z
dc.date.issued2024-04
dc.description.abstractMarine organisms, especially sponges, provide many sources of metabolites with various biological activities. Most sponges associate with microbes such as fungi. To solve the problem of sponge availability, it is necessary to isolate compounds from marine-derived fungi due to their feasibility and advantages. This study, thus, highlights that the most prominent genera to produce metabolites active as antibacterials and antibiofilm were Aspergillus, Penicillium, Neosartorya, and Trichoderma. The summarized data of isolated compounds related to antibacterial and antibiofilm activities until 2022 included anthraquinones, sterigmatocystin analogs, hydroxy pyrrolidine alkaloids, helvolic acid derivatives, lactones, prenylated phenylbutyrolactones, citrinin and derivatives, bisthiodiketopiperazine, cyclotetrapeptides, dihydrochromone dimers, amino lipopeptides, furan derivatives, aspiron-derivatives, halogenated metabolites, and alkaloids. Since the biofilm mechanism is very complex, some antibacterial compounds do not necessarily work as antibiofilms. Nevertheless, it can be concluded that compounds produced from sponge-associated fungi have the potential to be developed as new antibacterial and antibiofilm agents although still require further investigation related to the mechanism of actions of the compounds.en_US
dc.identifier.affiliationsDoctoral Program in Pharmaceutical Science, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Bachelor Pharmacy Study Program, Faculty of Health Sciences, Universitas dr Soebandi, Jember 68111, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Medicinal Plants and Natural Products Research Center Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Medicinal Plants and Natural Products Research Center Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Indonesia Biofilm Research Collaboration Center (IBRCC), Yogyakarta 55281, Indonesiaen_US
dc.identifier.affiliationsDrug Utilisation and Discovery Research Group, Faculty of Pharmacy, Universitas Jember, Jember 68121, Indonesia.en_US
dc.identifier.citationWigati D, Setyowati EP, Pratiwi SUT, Nugraha AS. Promising sponge derived marine fungi as antibacterial and biofilm inhibitors. Journal of Applied Pharmaceutical Science. 2024 Apr; 14(4): 14-34en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237604
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber4en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.161885en_US
dc.subjectMarine derive-fungien_US
dc.subjectantibacterialen_US
dc.subjectantibiofilmen_US
dc.subjectmetabolites activeen_US
dc.subjectdrug development.en_US
dc.titlePromising sponge derived marine fungi as antibacterial and biofilm inhibitorsen_US
dc.typeJournal Articleen_US
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