HIV and tuberculosis: partners in crime.

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dc.contributor.authorManiar, Janak Ken_US
dc.contributor.authorKamath, Ratnakar Ren_US
dc.contributor.authorMandalia, Sundhiyaen_US
dc.contributor.authorShah, Keyuren_US
dc.contributor.authorManiar, Aloken_US
dc.date.accessioned2009-05-28T08:22:04Z
dc.date.available2009-05-28T08:22:04Z
dc.date.issued2006-07-02en_US
dc.description.abstractBACKGROUND: Tuberculosis is the commonest infection detected in HIV-infected individuals worldwide. AIM: The aim of this study is to describe the clinical, bacteriologic and radiological spectrum of tuberculosis (TB) in the setting of human immunodeficiency virus (HIV) infection in a tertiary care centre in Mumbai. METHODS: A total of 8640 HIV-infected individuals were screened for tuberculosis routinely from January 1998 to December 2003, using clinical examination, chest X-ray and abdominal ultrasonography, sputum smears for acid-fast bacilli (AFB) and culture on Lowenstein-Jensen medium. RESULTS: TB was detected in 8078 (93.5%) patients of whom 3393 (42%) had pulmonary, 3514 (43.5%) had extrapulmonary TB and 1171 (14.5%) had disseminated disease. One thousand two hundred thirty eight patients (36.5%) showed AFB in sputum, while 1154 (34%) showed growth on culture medium and 4174 had radiographic involvement. In 781 (67%) individuals disseminated disease coexisted with pulmonary involvement. All 8078 coinfected patients were treated with anti-TB therapy (ATT), of whom 6422 patients (79.5%) showed one or more adverse events. Gastritis was the commonest complaint followed by hepatitis and skin rashes. ATT resistance was detected in 482 individuals. CONCLUSION: Tuberculosis is the commonest opportunistic infection (OI) in HIV positive patients in India, showing a higher prevalence of extrapulmonary and disseminated TB and adverse events due to ATT. Early recognition of concurrent OIs and their adequate treatment and prophylaxis is essential.en_US
dc.description.affiliationDepartment of Infectious Diseases, Jaslok Hospital and Research Centre, Mumbai, India, and Department of Medicine, Imperial College London, UK. jkmaniar@vsnl.comen_US
dc.identifier.citationManiar JK, Kamath RR, Mandalia S, Shah K, Maniar A. HIV and tuberculosis: partners in crime. Indian Journal of Dermatology, Venereology and Leprology. 2006 Jul-Aug; 72(4): 276-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/52503
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntitubercular Agents --therapeutic useen_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --complicationsen_US
dc.subject.meshHIV-1en_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMycobacterium tuberculosis --isolation & purificationen_US
dc.subject.meshOpportunistic Infections --complicationsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTuberculosis --diagnosisen_US
dc.titleHIV and tuberculosis: partners in crime.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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