An Observational Cohort Study on Prescription Patterns of Intravenous Albumin Use in Different Indications of Liver Disease

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dc.contributor.authorB., Ravi Shankaren_US
dc.contributor.authorB., Lakshminikhilaen_US
dc.contributor.authorG., Sailipien_US
dc.contributor.authorRampally, Vijayen_US
dc.contributor.authorE., Madhu Sudhanen_US
dc.date.accessioned2024-09-24T08:08:40Z
dc.date.available2024-09-24T08:08:40Z
dc.date.issued2023-02
dc.description.abstractIntroduction: Albumin is administered 20% as a part of treatment in various indications associated with decompensated liver disease. Methods: The study was conducted on patients over six months. Data were collected from 50 patients including males and females who are administered 20% albumin for liver cirrhosis. Disease severity before and after albumin infusion was calculated using prognostic tools like Child-Pugh and MELD-Na scoring system. Results: Among 50 patients, a major percent of patients were found to be HRS (28%) for albumin infusion and few extended indications were noticed; Decompensated liver cirrhosis without any other complications (18%), HE (18%), Hyponatremia (16%). After albumin infusion for six months, prognostic tools (CPT and MELD-Na scores) and laboratory parameters (serum creatinine, serum sodium, serum albumin) were significantly improved with P-value less than 0.05. Conclusion: Albumin usage has increased in some extended indications like decompensated liver cirrhosis without any other complications, hyponatremia, hepatic encephalopathy. Doses used in the present study were significantly less (when compared to standard doses as per the clinical guidelines) to minimize the adverse effects of albumin primarily pulmonary edema due to volume overload. Our study was consistent with the ANSWER trial where 20% albumin was used for the long term in decompensated liver cirrhosis.en_US
dc.identifier.affiliationsDirector, Department of Medical Gastroenterology, Yashoda Hospitals, Secunderabad, Telangana, Indiaen_US
dc.identifier.affiliationsPharm. D, Department of Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsPharm. D, Department of Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDNB 3rd Year, Department of Gastroenterology, Yashoda Hospitals, Secunderabad, Telangana, Indiaen_US
dc.identifier.affiliationsMSC, MBA, Clinical Research Administrator, Yashoda Hospitals, Secunderabad, Telangana, Indiaen_US
dc.identifier.citationB. Ravi Shankar, B. Lakshminikhila, G. Sailipi, Rampally Vijay, E. Madhu Sudhan. An Observational Cohort Study on Prescription Patterns of Intravenous Albumin Use in Different Indications of Liver Disease. International Journal of Medical Research Professionals. 2023 Jan; 9(1): 1-8en_US
dc.identifier.issn2454-6356
dc.identifier.issn2454-6364
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231019
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://doi.org/10.21276/ijmrp.2023.9.1.001en_US
dc.subjectHepatic encephalopathyen_US
dc.subjectHyponatremiaen_US
dc.subjectHypoalbuminemiaen_US
dc.subjectChild-Pugh Turcotteen_US
dc.subjectModel-End-Stage-Liver-Disease-Sodiumen_US
dc.subjectAlbuminen_US
dc.titleAn Observational Cohort Study on Prescription Patterns of Intravenous Albumin Use in Different Indications of Liver Diseaseen_US
dc.typeJournal Articleen_US
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