Drug-induced Kidney Disease: Revisited
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Date
2024-01
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Journal of Indian Medical Association
Abstract
Drug-induced kidney disease (DIKD) is a frequent cause of acute and chronic kidney disease (CKD) that leads to high morbidity, hospitalization, and increased healthcare costs. There is a need to constantly update our knowledge in this field, given the ever-burgeoning list of newer treatments that are emerging, especially in the field of cancer immunotherapy. Generalizing the complex pathways causing DIKD from different agents, the common mechanisms include direct toxicity, immune-mediated injury, and drug-induced alterations in renal blood flow. Proper management of this condition involves risk minimization, early detection of renal damage, and timely discontinuation of potential agents to avoid irreversible renal damage.
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Ganguli Anirban, Singh Narinder Pal. Drug-induced Kidney Disease: Revisited. Journal of the Association of Physicians of India. 2024 Jan; 72(1): 74–80