Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study

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dc.contributor.authorVohra, Gen_US
dc.contributor.authorRajendran, Nen_US
dc.contributor.authorKumari, A.en_US
dc.date.accessioned2025-08-13T09:54:23Z
dc.date.available2025-08-13T09:54:23Z
dc.date.issued2025-06
dc.description.abstractBackground: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in CKD patients and often persists after renal transplantation. Dual-energy X-ray absorptiometry (DXA) assesses bone mineral density (BMD), while bone biomarkers provide insight into bone turnover. This study evaluates bone disease in CKD and post-transplant patients using DXA and bone biomarkers to assess changes in BMD and metabolic bone parameters post-transplantation. Methods: This observational study included CKD patients and post-transplant recipients. BMD was measured at the spine, femur, and radius using DXA. Bone turnover markers, including parathyroid hormone (PTH), vitamin D3, calcium, phosphorus, and osteocalcin, were analyzed. Comparative statistical analysis was performed to assess differences between CKD and post-transplant groups. Results: Mean BMD at the femur and radius did not differ significantly between CKD and post-transplant patients (p > 0.05). Osteopenia was the most prevalent bone abnormality in both groups. No significant correlation was found between calcium, phosphorus, and PTH levels, but PTH and osteocalcin were significantly associated (p = 0.02). A significant relationship was also found between BMD at the radius and T-score at the spine (p = 0.008). Conclusion: Bone disease persists in CKD and post-transplant patients, highlighting the need for long-term monitoring and tailored interventions.en_US
dc.identifier.affiliationsDepartment of Nephrology, INM, INHS Sandhani, Mumbai, Indiaen_US
dc.identifier.affiliationsDepartment of General Surgery, 15 Air Force Hospital, Jaisalmer, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmologist, Laxmi Eye Hospital, Panvel, Mumbaien_US
dc.identifier.citationVohra G, Rajendran N, Kumari A. . Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study. National Journal of Medical Research . 2025 Jun; 15(2): 160-163en_US
dc.identifier.issn2249-4995
dc.identifier.issn2277-8810
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252794
dc.languageenen_US
dc.publisherMedsci Publicationsen_US
dc.relation.issuenumber2en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.55489/njmr.150220251082en_US
dc.subjectChronic kidney diseaseen_US
dc.subjectrenal transplantationen_US
dc.subjectbone mineral densityen_US
dc.subjectDXA scanen_US
dc.subjectosteopeniaen_US
dc.subjectosteoporosisen_US
dc.subjectbone biomarkersen_US
dc.subjectparathyroid hormoneen_US
dc.subjectvitamin D3en_US
dc.subjectosteocalcinen_US
dc.titleEvaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Studyen_US
dc.typeJournal Articleen_US
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