Rheumatoid arthritis: new developments in biologic therapy.

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dc.contributor.authorMahajan, Annilen_US
dc.contributor.authorSharma, Rashmien_US
dc.contributor.authorKhajuria, Ruchien_US
dc.contributor.authorBardi, Ghulam Hussainen_US
dc.contributor.authorKapoor, Bhuvneshwaren_US
dc.contributor.authorGupta, Vijayen_US
dc.date.accessioned2006-06-25en_US
dc.date.accessioned2009-05-31T07:44:58Z
dc.date.available2006-06-25en_US
dc.date.available2009-05-31T07:44:58Z
dc.date.issued2006-06-25en_US
dc.description.abstractWith the development of biologic agents our therapeutic approach to rheumatoid arthritis (RA) and inflammatory diseases in general, has dramatically changed within the last few years. Biologic technically means a substance as the product of biologic system and functionally as an agent that targets specific biologic molecule. Recently a number of endogenous antigens have been identified and these are known to activate CD4+ T cells leading to production of cytokines [interleukin (IL)-1, IL-6] and tumour necrosis factor (TNF)-alpha and immunoglobulins like rheumatoid factor and expression of osteoprotegerin ligands that stimulate osteogenesis leading to joint distruction. Rheumatologists and other practitioners are facing a remarkable wave of new therapies for RA like infliximab, adalimumab, atlizumab, etanercept, anakinra, prosorbacolumn, anti-IL-6 agents, IL-10 and inferferon-r. To date combination therapy of methotrexate plus a single biologic has been widely studied with synergistic effect. Etanercept and infliximab are two biologics available in India.en_US
dc.description.affiliationPostgraduate Department of General Medicine, Government Medical College, Jammu 180016.en_US
dc.identifier.citationMahajan A, Sharma R, Khajuria R, Bardi GH, Kapoor B, Gupta V. Rheumatoid arthritis: new developments in biologic therapy. Journal of the Indian Medical Association. 2006 Jun; 104(6): 327-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/97151
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAntibodies, Monoclonal --therapeutic useen_US
dc.subject.meshArthritis, Rheumatoid --immunologyen_US
dc.subject.meshBiological Therapy --trendsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin G --therapeutic useen_US
dc.subject.meshInterleukin-1en_US
dc.subject.meshInterleukin-10en_US
dc.subject.meshReceptors, Tumor Necrosis Factor --therapeutic useen_US
dc.subject.meshTumor Necrosis Factor-alphaen_US
dc.titleRheumatoid arthritis: new developments in biologic therapy.en_US
dc.typeJournal Articleen_US
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