Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis

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dc.contributor.authorKumar, Ashoken_US
dc.contributor.authorJoshi, Jawahar Lalen_US
dc.contributor.authorUmathoor, Abdurazacken_US
dc.contributor.authorChopra, Vishalen_US
dc.contributor.authorKaur, Komaldeepen_US
dc.contributor.authorMittal, Vidhuen_US
dc.date.accessioned2020-11-18T09:59:36Z
dc.date.available2020-11-18T09:59:36Z
dc.date.issued2019-09
dc.description.abstractBackground: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients.Method: A prospective study 100 newly diagnosed sputum smear positive pulmonary TB patients was conducted. The patients with an age of ≥15 years and who had either not taken anti TB treatment or who had taken ATT for less than 1 month were enrolled in this study. Two sputum samples (5ml each), including one early morning sample as per the RNTCP guidelines were collected and subjected to line probe assay (LPA).Results: Out of 100 cases 6 were having resistance to both rifampicin and isoniazid, 9 has resistance to INH alone and 1 had resistance to rifampicin alone.Conclusion: The prevalence of primary drug resistance is high. For early and rapid detection of DR-TB newer modality should be used  for the detection of primary drug resistance in sputum smear positive TB patients.en_US
dc.identifier.affiliationsDepartment of Microbiology, Government Medical College, Patiala, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Chest and TB, Government Medical College, Patiala, Punjab, Indiaen_US
dc.identifier.citationKumar Ashok, Joshi Jawahar Lal, Umathoor Abdurazack, Chopra Vishal, Kaur Komaldeep, Mittal Vidhu. Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis. International Journal of Research in Medical Sciences. 2019 Sep; 7(9): 3532-3535en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211733
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20193942en_US
dc.subjectMulti-drug-resistant tuberculosisen_US
dc.subjectPrevalenceen_US
dc.subjectResistanceen_US
dc.titlePrevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosisen_US
dc.typeJournal Articleen_US
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