p53 expression in pterygium in two climatic regions in Turkey.

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dc.contributor.authorPelit, Ayselen_US
dc.contributor.authorBal, Nebilen_US
dc.contributor.authorAkova, Yonca Aen_US
dc.contributor.authorDemirhan, Beyhanen_US
dc.date.accessioned2009-05-23en_US
dc.date.accessioned2009-05-29T08:49:20Z
dc.date.available2009-05-23en_US
dc.date.available2009-05-29T08:49:20Z
dc.date.issued2009-05-23en_US
dc.description.abstractPurpose: To assess accumulation of p53 protein in samples of primary pterygium from people living in two different climatic regions in Turkey. Materials and Methods: Group 1 included 101 pterygium specimens from people in Adana located in southern Turkey. Group 2 included 39 pterygium specimens from people in Ankara, located in the middle of Turkey. Climatic conditions throughout the year are sunnier and warmer in Adana than they are in Ankara. The control group (Group 3) included 30 specimens of conjunctiva that had been excised during cataract surgery from 30 patients without pterygium. The pterygial specimens and control conjunctiva were studied by immunohistochemistry using antibodies against p53 protein. Pearson's chi-square test was used to compare the p53 immunoreactivity. Results: The p53 immunoreactivity in Groups 1 and 2 was greater than it was in the control group ( P 0.001). There were no differences in p53 immunoreactivity between Groups 1 and 2 ( P= 0.060). Conclusion: The p53 immunoreactivity was not correlated with ultraviolet irradiation exposure. The p53 immunoreactivity in our pterygium specimens suggests that pterygium could be a result of uncontrolled cell proliferation.en_US
dc.description.affiliationDepartment of Ophthalmology, Baskent University School of Medicine, Adana Teaching and Medical Research Center, Adana, Turkey. aypelit@yahoo.com.en_US
dc.identifier.citationPelit A, Bal N, Akova YA, Demirhan B. p53 expression in pterygium in two climatic regions in Turkey. Indian Journal of Ophthalmology. 2009 May-Jun; 57(3): 203-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/70908
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683445/en_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshClimate
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPterygium --metabolism
dc.subject.meshPterygium --surgery
dc.subject.meshTumor Suppressor Protein p53 --metabolism
dc.subject.meshTurkey
dc.titlep53 expression in pterygium in two climatic regions in Turkey.en_US
dc.typeJournal Articleen_US
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