All-transretinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia.

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dc.contributor.authorAl Bahar, Sen_US
dc.contributor.authorPandita, Ren_US
dc.contributor.authorBavishi, Ken_US
dc.contributor.authorKreze, Oen_US
dc.date.accessioned2009-05-28T06:30:23Z
dc.date.available2009-05-28T06:30:23Z
dc.date.issued2004-07-09en_US
dc.description.abstractBACKGROUND: All-transretinoic acid (ATRA) and chemotherapy has improved complete remission rates and disease free survival in acute promyelocytic leukemia (APL). There is scanty data from Middle East. AIM: To determine the efficacy of ATRA and multi-agent combination chemotherapy in treatment of APL in a single Centre in Kuwait. SET-UPS AND DESIGN: Tertiary cancer centre, retrospective study. METHODS AND MATERIAL: All newly diagnosed APL patients were treated with oral ATRA 45 mg/m2 daily until complete remission (CR), intravenous daunorubicin 50 mg/m2 on days 1,3 and 5, cytosine arabinoside 100 mg/m2 12 hrly on days 1 through 10 and etoposide 100 mg/m2 on days 1 through 5. Post remission three courses of intensive consolidation chemotherapy were administered. Since October 1999, maintenance chemotherapy consisting of oral 6 mercaptopurine 9 mg/m2 daily, methotrexate 15 mg/m2 weekly and ATRA 45 mg/m2 for 2 weeks every three months was added. Complete remission rates and duration, relapse rate and toxicity were studied. RESULTS: 22 of 24 evaluable patients (91.6%) achieved CR. The median duration of remission was 13 months (range 2-55 months). Three patients (12.5%) relapsed. Two patients (8.3%) developed retinoic acid syndrome and responded to dexamethasone. Five patients (20.8%) died one each of refractory disease, during remission induction and of relapse. Two patients died while in remission. CONCLUSION: ATRA and combination chemotherapy results in high complete remission rates and low relapse rate in newly diagnosed APL. Maintenance therapy may be useful in preventing relapses.en_US
dc.description.affiliationDepartment of Hematology, Kuwait Cancer Control Centre, Shuwaikh, Kuwait. soleman97@hotmail.com.en_US
dc.identifier.citationAl Bahar S, Pandita R, Bavishi K, Kreze O. All-transretinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia. Indian Journal of Cancer. 2004 Jul-Sep; 41(3): 125-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/49943
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.subject.mesh6-Mercaptopurine --administration & dosageen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic useen_US
dc.subject.meshCytarabine --administration & dosageen_US
dc.subject.meshDaunorubicin --administration & dosageen_US
dc.subject.meshEtoposide --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Promyelocytic, Acute --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMethotrexate --administration & dosageen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Local --drug therapyen_US
dc.subject.meshRemission Inductionen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshTretinoin --administration & dosageen_US
dc.titleAll-transretinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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