Clinical and Laboratory Characteristics and Comorbidities in Asthma Endotypes in Children

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dc.contributor.authorKumar, Gautamen_US
dc.contributor.authorTripathy, Saroj Kumaren_US
dc.contributor.authorDas, Sarthaken_US
dc.contributor.authorMalik, Archanaen_US
dc.contributor.authorV, Vinayagamoorthyen_US
dc.date.accessioned2025-08-13T09:09:42Z
dc.date.available2025-08-13T09:09:42Z
dc.date.issued2025-01
dc.description.abstractOBJECTIVE To estimate the proportion of eosinophilic and non-eosinophilic (NEA) endotypes in pediatric asthma, and to compare the clinical, and laboratory characteris?cs, and different comorbidities between the two endotypes in the children. METHODS Children aged 5 to 14 years of age with clinical and/or laboratory- confirmed asthma a?ending the pediatric outpa?ent department of a ter?ary care hospital in Eastern India between October 1, 2023 and March 31, 2024, were included in this cross-sec?onal study. Complete hemogram, absolute eosinophil count (AEC), IgE, and pulmonary func?on tests were performed in all patients. Comorbidi?es associated with asthma were recorded. All patients were managed as per the Global Initiative for Asthma (GINA) guidelines. RESULTS Of 150 pa?ents, 133 (88.7%) pa?ents belonged to eosinophilic asthma and 17 (11.3%) belonged to NEA endotypes. A family history of allergy and/or asthma was observed in 83 (55%) par?cipants. Allergic rhini?s (59.3%), exposure to cold (42%), and anxiety (26.7%) were common comorbidi?es associated with asthma. Prematurity and urticaria were significantly associated with NEA. On regression analysis, the odds of ur?caria among the NEA endotype were about 3.7 ?mes higher than the EA endotype, adjusted odds ra?o (95% CI) of 4 (1.3, 12.6), P value = 0.02. Other comorbidi?es, sociodemographic, clinical, and lung function values were similar in both endotypes of asthma. CONCLUSION Eosinophilic asthma is the commonest asthma endotype and allergic rhini?s is the commonest comorbidity observed in children. Comorbidities associated with asthma in children are usually similar in both endotypes except for ur?caria which is higher in NEA.en_US
dc.identifier.affiliationsMBBS student, All India Institute of Medical Sciences, Deoghar, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, Indiaen_US
dc.identifier.affiliationsPulmonary, All India Institute of Medical Sciences, Deoghar, Jharkhand, Indiaen_US
dc.identifier.affiliationsCommunity and Family Medicine, All India Institute of Medical Sciences, Deoghar, Jharkhand, Indiaen_US
dc.identifier.citationKumar Gautam, Tripathy Saroj Kumar, Das Sarthak, Malik Archana, V Vinayagamoorthy. Clinical and Laboratory Characteristics and Comorbidities in Asthma Endotypes in Children. Indian Pediatrics. 2025 Jan; 62(1): 44-48en_US
dc.identifier.issn0019-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251354
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber1en_US
dc.relation.volume62en_US
dc.source.urihttps://indianpediatrics.net/jan2025/44.pdfen_US
dc.subjectAllergyen_US
dc.subjectAsthmaen_US
dc.subjectEosinophiliaen_US
dc.subjectUrticariaen_US
dc.titleClinical and Laboratory Characteristics and Comorbidities in Asthma Endotypes in Childrenen_US
dc.typeJournal Articleen_US
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