An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis.

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dc.contributor.authorJaiswal, Amiten_US
dc.contributor.authorSharma, R Pen_US
dc.contributor.authorGarg, A Pen_US
dc.date.accessioned2009-05-28T08:28:46Z
dc.date.available2009-05-28T08:28:46Z
dc.date.issued2007-11-23en_US
dc.description.abstractBACKGROUND: Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts and molds. AIMS: To study the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in onychomycosis. METHODS: A clinical comparative study was undertaken on 96 Patients of onychomycosis during the period between August 2005 to July 2006. Forty-eight patients were randomly assigned in group A to receive oral terbinafine 250 mg, one tablet twice daily for seven days every month (pulse therapy); 24 patients in group B to receive oral terbinafine pulse therapy plus topical ciclopirox olamine 8% to be applied once daily at night on all affected nails; and 24 patients in group C to receive oral terbinafine pulse therapy plus topical amorolfine hydrochloride 5% to be applied once weekly at night on all the affected nails. The treatment was continued for four months. The patients were evaluated at four weekly intervals till sixteen weeks and then at 24 and 36 weeks. RESULTS: We observed clinical cure in 71.73, 82.60 and 73.91% patients in groups A, B and C, respectively; Mycological cure rates against dematophytes were 88.9, 88.9 and 85.7 in groups A, B and C, respectively. The yeast mycological cure rates were 66.7, 100 and 50 in groups A, B and C, respectively. In the case of nondermatophytes, the overall response was poor: one out of two cases (50%) responded in group A, while one case each in group B and group C did not respond at all. CONCLUSION: Terbinafine pulse therapy is effective and safe alternative in treatment of onychomycosis due to dermatophytes; and combination therapy with topical ciclopirox or amorolfine do not show any significant difference in efficacy in comparison to monotherapy with oral terbinafine.en_US
dc.description.affiliationDepartment of Dermatology and Venereology, L. L. R. M. Medical College, Meerut, Uttar Pradesh, India.en_US
dc.identifier.citationJaiswal A, Sharma RP, Garg AP. An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis. Indian Journal of Dermatology, Venereology and Leprology. 2007 Nov-Dec; 73(6): 393-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/52669
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdministration, Topicalen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntifungal Agents --economicsen_US
dc.subject.meshChilden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFoot Dermatoses --drug therapyen_US
dc.subject.meshHand Dermatoses --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMorpholines --economicsen_US
dc.subject.meshNaphthalenes --economicsen_US
dc.subject.meshOnychomycosis --drug therapyen_US
dc.subject.meshPyridones --economicsen_US
dc.subject.meshSingle-Blind Methoden_US
dc.titleAn open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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