Value of the strain ratio in the differential diagnosis of intraocular tumors by elastosonography: A retrospective case-control study

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dc.contributor.authorChen, Weien_US
dc.contributor.authorYang, Wenlien_US
dc.contributor.authorLi, Dongjunen_US
dc.contributor.authorWang, Ziyangen_US
dc.contributor.authorZhao, Qien_US
dc.contributor.authorLi, Yifengen_US
dc.contributor.authorCui, Ruien_US
dc.contributor.authorShen, Linen_US
dc.date.accessioned2023-08-25T06:36:26Z
dc.date.available2023-08-25T06:36:26Z
dc.date.issued2023-03
dc.description.abstractPurpose: To examine the role of the strain ratio in elastosonography for the differential diagnosis of common intraocular tumors such as choroidal melanoma, choroidal hemangioma, choroidal metastatic carcinoma, and retinoblastoma. Methods: This study included patients suffering from intraocular space?occupying lesions and who visited Beijing Tongren Eye Center of Beijing Tongren Hospital affiliated to Capital Medical University from June 2016 to March 2020. All patients underwent a physical examination, fundus examination with mydriasis, color Doppler ultrasonography, elastosonography, magnetic resonance imaging (MRI), and fundus angiography within 1 week. All patients were grouped as choroidal melanoma, choroidal metastatic carcinoma, retinoblastoma, choroidal hemangioma, and optic disk melanocytoma. A receiver operating characteristic (ROC) curve analysis was performed to assess the strain ratio for diagnosing malignant intraocular tumors. Results: A total of 155 patients (161 eyes) were recruited. The strain ratios measured were 39.59 ± 15.92 for choroidal melanoma, 36.85 ± 13.64 for choroidal metastatic carcinoma, 38.93 ± 17.27 for retinoblastoma, 13.42 ± 10.93 for choroidal hemangioma, and 3.84 ± 1.32 for optic disk melanocytoma. The strain ratios of the three malignant lesions were significantly higher than those of the two benign lesions (all P < 0.001). The area under the ROC curve was 0.95 ± 0.028. The optimal cutoff point was 22.67, with 85.7% sensitivity and 96.4% specificity. Conclusion: There were significant differences in elasticity between the malignant and benign intraocular tumors. The strain ratio using elastosonography could serve as an important auxiliary examination to distinguish between benign and malignant intraocular tumorsen_US
dc.identifier.affiliationsBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumour Diagnosis and Treatment, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Dongcheng District, Beijingen_US
dc.identifier.citationChen Wei, Yang Wenli, Li Dongjun, Wang Ziyang, Zhao Qi, Li Yifeng, Cui Rui, Shen Lin. Value of the strain ratio in the differential diagnosis of intraocular tumors by elastosonography: A retrospective case-control study. Indian Journal of Ophthalmology. 2023 Mar; 71(3): 983-988en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224910
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber3en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1397_22en_US
dc.subjectColor Doppler ultrasounden_US
dc.subjectdiagnosisen_US
dc.subjectelastographyen_US
dc.subjectintraocular tumoren_US
dc.subjectstrain ratioen_US
dc.titleValue of the strain ratio in the differential diagnosis of intraocular tumors by elastosonography: A retrospective case-control studyen_US
dc.typeJournal Articleen_US
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