"An analysis of epileptic patients nonresponsive to drugs".

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dc.contributor.authorKarande, S Cen_US
dc.contributor.authorJoshi, M Ven_US
dc.contributor.authorKshirsagar, N Aen_US
dc.contributor.authorShah, P Uen_US
dc.date.accessioned1992-07-01en_US
dc.date.accessioned2009-05-31T02:44:51Z
dc.date.available1992-07-01en_US
dc.date.available2009-05-31T02:44:51Z
dc.date.issued1992-07-01en_US
dc.description.abstractFifty-four consecutively referred patients with uncontrolled epilepsy were subjected to Therapeutic Drug Monitoring on an out patient basis. Regular 2 weekly follow up for a minimum period of 2 months was done, after altering the drug dosage and bringing plasma level(s) within therapeutic range. Plasma levels of Phenobarbitone, Phenytoin and Carbamezepine were done by High Pressure Liquid Chromatography. Eventually, 24 patients were controlled and 30 remained uncontrolled. Significant differences between these 2 groups were found, as regards, duration of epilepsy (p < 0.01), associated mental retardation (p < 0.02), initial carbamazepine dosage and plasma levels in patients on carbamazepine montherapy (p < 0.02 and P < 0.01, respectively) and final phenytoin plasma levels in patients on combined therapy with phenobarbitone and phenytoin (p < 0.05). This study emphasizes the importance of early diagnosis and treatment of epilepsy with the help of plasma level monitoring of anti-epileptic drugs.en_US
dc.description.affiliationDept of Pharmacology, Seth GS Medical College, Parel, Bombay.en_US
dc.identifier.citationKarande SC, Joshi MV, Kshirsagar NA, Shah PU. "An analysis of epileptic patients nonresponsive to drugs". Journal of the Association of Physicians of India. 1992 Jul; 40(7): 445-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/93307
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAnticonvulsants --administration & dosageen_US
dc.subject.meshCarbamazepine --administration & dosageen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Monitoringen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshEpilepsy --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenobarbital --administration & dosageen_US
dc.subject.meshPhenytoin --administration & dosageen_US
dc.subject.meshTreatment Failureen_US
dc.title"An analysis of epileptic patients nonresponsive to drugs".en_US
dc.typeJournal Articleen_US
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