A comparative study of physical parameters of selected ketorolac tromethamine tablets available in the pharma market of Bangladesh.
Loading...
Date
2011-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Quality of pharmaceutical product is very important because drugs must be marketed
as safe and therapeutically active formulations whose performance is consistent and predictable.
The evaluation of the physical characteristics of the pharmaceutical products can ensure their
quality as well as bioavailability and impart optimum therapeutic activity. Ketorolac
tromethamine was chosen for this comparative study because this drug is widely used worldwide
for treating moderate to severe pain. The present study compared the weight variation, hardness
and the abrasion withstanding ability of eight brands of Ketorolac tromethamine tablets marketed
in Bangladesh following USP guidelines. All eight brands of Ketorolac tromethamine tested
conformed to the USP weight variation test. All the brands had average hardness of ≥3 kg which
was satisfactory for immediate release tablet like ketorolac tromethamine. All the brands had
shown their friability variation within ±1% range specified by USP. Standard deviation was
calculated among all the brands which was very close to individual percentage friability of all the
brands. All the brands of ketorolac tromethamine complied with USP requirements of physical
quality parameters. It follows that these brands will show good disintegration and dissolution
profile which would further help in achieving optimum bioavailability and in fulfilling the patient
demands.
Description
Keywords
Ketorolac tromethamine, weight variation, hardness, friability, USP
Citation
Nasrin Nishat, Asaduzzaman Muhammad, Mowla Rumana, Rizwan Farhana, Alam Ashiqul. A comparative study of physical parameters of selected ketorolac tromethamine tablets available in the pharma market of Bangladesh. Journal of Applied Pharmaceutical Science. 2011 Oct; 1(8): 101-103.