Plasmapheresis for the preparation of HIV free cryoprecipitate.

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dc.contributor.authorTardtong, Pen_US
dc.contributor.authorChuansumrit, Aen_US
dc.contributor.authorStabanswadigan, Sen_US
dc.contributor.authorChiewsilp, Pen_US
dc.contributor.authorIsarangkura, Pen_US
dc.date.accessioned2009-05-27T16:13:06Z
dc.date.available2009-05-27T16:13:06Z
dc.date.issued1993-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractSingle donor cryoprecipitate was prepared by blood cell separator for treatment of hemophilia A and von Willebrand patients to reduce a risk of transfusion associated HIV infection. A total of 7 plasmapheresis (range 1-1.5 plasma volume) was performed in 4 donors. Then fresh frozen plasma (FFP) was processed to cryoprecipitate and cryoprecipitate removed plasma (CRP). Donors were replaced with 0.9% normal saline solution (NSS) and 5% albumin for the first donation or their own CRP and 5% albumin for the second and third donation. After plasmapheresis total protein, albumin, IgG, IgA and IgM were below normal level in 71.43% (5/7), 14.3% (1/7), 28.57% (2/7), 14.3% (1/7) and 28.57% (2/7), respectively. All of these parameters returned to normal level within 3 days. Factor VIII:C was decreased after plasmapheresis in all donors and the low level of F VIII:C returned to normal within 24 hours. The donor was not exposed to any harmful effect. Donor reactions observed were mild. One donor was chilled due to unwarmed replacement solution. When this donor donated for the second time and was replaced with prewarmed replacement solution, no reaction was observed. We conclude that a preparation of single donor cryoprecipitate by plasmapheresis is safe and can reduce a risk of transfusion associated HIV infection. The donors are not at risk as the result of changes in the measured plasma protein and factor VIII:C level following plasmapheresis.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationTardtong P, Chuansumrit A, Stabanswadigan S, Chiewsilp P, Isarangkura P. Plasmapheresis for the preparation of HIV free cryoprecipitate. The Southeast Asian Journal of Tropical Medicine and Public Health. 1993 ; 24 Suppl 1(): 195-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34698
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Component Transfusion --adverse effectsen_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshFactor VIII --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinogen --analysisen_US
dc.subject.meshHIV Infections --etiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfection Control --methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshPlasmapheresisen_US
dc.titlePlasmapheresis for the preparation of HIV free cryoprecipitate.en_US
dc.typeJournal Articleen_US
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