The role of histone modifications in leukemogenesis

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dc.contributor.authorBirch, Noah Wen_US
dc.contributor.authorShilatifard, Alien_US
dc.date.accessioned2020-11-18T10:14:25Z
dc.date.available2020-11-18T10:14:25Z
dc.date.issued2020-01
dc.description.abstractHistone modifications play a critical role in coordinating accurate gene expression. Aside from geneticmutations which cause altered DNA sequence, it has become increasingly clear that aberrant post-translationalmodifications of histone tails are also associated with leukemogenesis. The functional roles of specific histonemarks has informed the basis of our understanding for underlying mechanisms of leukemia, while globalanalyses of interacting histone modifications has begun to distinguish subtypes of leukemia with prognosticand therapeutic implications. In this current era of personalized and precision medicine, it will be necessary tonot only identify the specific genetic mutations present in a patient’s leukemia but to also appreciate thedynamic chromatin states which are driven by histone modifications that can aid our diagnostic and therapeuticstrategies for improved management of leukemia.en_US
dc.identifier.affiliationsSimpson Querrey Center for Epigenetics, and the Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAen_US
dc.identifier.affiliationsDivision of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAen_US
dc.identifier.affiliationsSimpson Querrey Center for Epigenetics, and the Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAen_US
dc.identifier.citationBirch Noah W, Shilatifard Ali. The role of histone modifications in leukemogenesis. Journal of Biosciences. 2020 Jan; : 1-5en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214362
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.volume45en_US
dc.source.urihttps://dx.doi.org//10.1007/s12038-019-9969-0en_US
dc.subjectHistone modificationen_US
dc.subjectleukemiaen_US
dc.subjectchromatinen_US
dc.subjectmethylationen_US
dc.subjectacetylationen_US
dc.titleThe role of histone modifications in leukemogenesisen_US
dc.typeJournal Articleen_US
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