Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma.

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dc.contributor.authorSubhalakshmi, Ven_US
dc.contributor.authorJaiswal, Ren_US
dc.contributor.authorPriyadharshini, IKen_US
dc.contributor.authorAmbika, Men_US
dc.date.accessioned2025-08-13T10:00:10Z
dc.date.available2025-08-13T10:00:10Z
dc.date.issued2025-03
dc.description.abstractOral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030. Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation. Another major factor is apoptosis which is programmed cell death. Apoptosis generally happens in two pathways Extrinsic pathway which involves trans-membrane receptor-mediated interaction and by Intrinsic pathway which is a mitochondrial-initiated event. There are Pro-apoptotic genes that support apoptosis like Caspases, TNF, and P53 families, and Anti-apoptotic genes like BCL-2 which stop the programmed cell death leading to cellular proliferation and tumor progression. This study was done to find the role of the anti-apoptotic protein BCL2 in varying histological grades of oral squamous cell carcinoma by immunohistochemistry.en_US
dc.identifier.affiliationsResearch Associate, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed to Be University), Salemen_US
dc.identifier.affiliationsProfessor and Head, Department of Oral and Maxillofacial Pathology and Microbiology, Sardar Patel Postgraduate Institute of Medical and Dental Sciences, Lucknowen_US
dc.identifier.affiliationsAssociate Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed to Be University), Salemen_US
dc.identifier.affiliationsAssociate Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed to Be University), Salemen_US
dc.identifier.citationSubhalakshmi V, Jaiswal R, Priyadharshini IK, Ambika M. Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma.. Online Journal of Health and Allied Sciences. 2025 Mar; 24(93): 1-5en_US
dc.identifier.issn0972-5997
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252876
dc.languageenen_US
dc.publisherLight House Polyclinicen_US
dc.relation.issuenumber93en_US
dc.relation.volume24en_US
dc.source.urihttps://www.ojhas.org/issue93/2025-1-3.pdfen_US
dc.subjectBCL2en_US
dc.subjectImmunohistochemistryen_US
dc.subjectApoptosisen_US
dc.subjectCaspasesen_US
dc.titleImmunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma.en_US
dc.typeJournal Articleen_US
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