Chromosomal abnormalities and hormonal disorders of primary amenorrhea patients in Egypt.

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dc.contributor.authorEl-Dahtory, Faeza
dc.date.accessioned2012-11-21T10:03:31Z
dc.date.available2012-11-21T10:03:31Z
dc.date.issued2012-05
dc.description.abstractBackground: Primary amenorrhea is defined as the absence of menstruation and secondary sexual characteristics in phenotypic women aged 14 years or older. Hormonal disorders are main causes of primary amenorrhea. Common hormonal cause of primary amenorrhea includes pituitary dysfunction and absent ovarian function. The aim of this study was to estimate the incidence and types of chromosomal abnormalities in patients with primary amenorrhea in Egypt. Materials and Methods: Chromosomal analysis and hormonal assay were carried out on 223 patients with primary amenorrhea that were referred from different parts of Egypt to Cytogenetic laboratory of Genetic Unit, Children Hospital Mansoura University, from July 2008 to December 2010. FISH technique was carried out in some of cases to more evaluation. Results: The frequency of chromosomal abnormalities was 46 (20.63%) in primary amenorrhea patients. The chromosomal abnormalities can be classified into four main types. (1) The numerical abnormalities of the X chromosome were detected in 23 (50 %). (2) Structural abnormalities of the X chromosome were detected in 11 (23.91%). (3) Mosaicism of X chromosome was found in 10 (21.74%). (4) Male karyotype 46, XY was presented in 2 (4.35%). Conclusion: The present study showed that karyotype and FISH are necessary to detect the causes of primary amenorrhea. This study also revealed the incidence of chromosomal abnormalities in women with primary amenorrhea in Egypt is similar to that reported in previous literatures.en_US
dc.identifier.citationEl-Dahtory Faeza. Chromosomal abnormalities and hormonal disorders of primary amenorrhea patients in Egypt. Indian Journal of Human Genetics. 2012 May; 18(2): 183-186.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/143268
dc.language.isoenen_US
dc.source.urihttps://www.ijhg.com/article.asp?issn=0971-6866;year=2012;volume=18;issue=2;spage=183;epage=186;aulast=El-Dahtoryen_US
dc.subjectCytogenetic studyen_US
dc.subjectprimary amenorrheaen_US
dc.subjectkaryotypeen_US
dc.subjectFluorescence in situ hybridizationen_US
dc.subject.meshAmenorrhea --epidemiology
dc.subject.meshAmenorrhea --genetics
dc.subject.meshChromosome Aberrations --genetics
dc.subject.meshChromosomes, Human, X --genetics
dc.subject.meshDisorders of Sex Development --genetics
dc.subject.meshEgypt
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence --methods
dc.subject.meshKaryotype
dc.titleChromosomal abnormalities and hormonal disorders of primary amenorrhea patients in Egypt.en_US
dc.typeArticleen_US
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