Individualized and inverse optimized needle configuration for combined intracavitary-interstitial brachytherapy in locally advanced cervical cancer

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dc.contributor.authorZhang, Daguangen_US
dc.contributor.authorYang, Zhiyongen_US
dc.contributor.authorJiang, Shanen_US
dc.contributor.authorZhou, Linen_US
dc.contributor.authorZhou, Zeyangen_US
dc.contributor.authorWang, Weien_US
dc.date.accessioned2020-11-18T10:07:33Z
dc.date.available2020-11-18T10:07:33Z
dc.date.issued2020-01
dc.description.abstractObjectives: The aim of this study is to address the limitation of combined intracavitary-interstitial (IC/IS) brachytherapy (BT) in locally advanced cervical cancer using standardized applicators and to determine the optimal dose distribution in patients with challenging tumors, innovative methods of customizing and optimizing the IS needle configuration for combined IC/IS BT are proposed and investigated. Materials and Methods: A software module that could customize the IS needle configuration and subsequently generate the digital model of guiding template for three-dimensional printing was developed and integrated into our in-house treatment planning system for BT. The inverse optimization method based on the technique of mixed-integer linear programming was introduced to determine the needle tracks out of a candidate pool and dwell times at corresponding locations to best meet dose objectives. A treatment planning study was conducted to evaluate the feasibility and performance of the proposed methods. Results: The workflow for combined IC/IS BT with customized and inverse optimized IS needle configuration was presented. Dosimetric results of the treatment planning study showed that sufficient target coverage could be obtained with the customized IS needle configuration for challenging cases. The proposed dose-based optimization method for IS needle configuration was feasible and effective. Improved target coverage and organ-at-risk sparing were achieved using the inverse planning method. Conclusions: Using the proposed methods of customizing and optimizing the IS needle configuration, the limitation in the standardized design of combined IC/IS applicators can be addressed, and sufficient target coverage is obtained in cervical cancer patients with unfavorable tumor topography and/or extra lateral expansion.en_US
dc.identifier.affiliationsSchool of Mechanical Engineering, Tianjin University, Tianjin, Chinaen_US
dc.identifier.affiliationsSchool of Mechanical Engineering, Tianjin University, Tianjin, Chinaen_US
dc.identifier.affiliationsSchool of Mechanical Engineering, Tianjin University, Tianjin, Chinaen_US
dc.identifier.affiliationsSchool of Mechanical Engineering, Tianjin University, Tianjin, Chinaen_US
dc.identifier.affiliationsSchool of Mechanical Engineering, Tianjin University, Tianjin, Chinaen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, Chinaen_US
dc.identifier.citationZhang Daguang, Yang Zhiyong, Jiang Shan, Zhou Lin, Zhou Zeyang, Wang Wei. Individualized and inverse optimized needle configuration for combined intracavitary-interstitial brachytherapy in locally advanced cervical cancer. Journal of Cancer Research and Therapeutics. 2020 Jan; 15(6): 1589-1596en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213575
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber6en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_292_19en_US
dc.subjectApplicatorsen_US
dc.subjectcervical canceren_US
dc.subjectcombined intracavitary-interstitial brachytherapyen_US
dc.subjectindividualized designen_US
dc.subjectinverse treatment planningen_US
dc.titleIndividualized and inverse optimized needle configuration for combined intracavitary-interstitial brachytherapy in locally advanced cervical canceren_US
dc.typeJournal Articleen_US
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