In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.

Simple item page
dc.contributor.authorDhople, A Men_US
dc.contributor.authorLamoureux, L Cen_US
dc.contributor.authorGardner, G Den_US
dc.date.accessioned1991-04-01en_US
dc.date.accessioned2009-05-28T09:51:52Z
dc.date.available1991-04-01en_US
dc.date.available2009-05-28T09:51:52Z
dc.date.issued1991-04-01en_US
dc.description.abstractInteractions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.en_US
dc.description.affiliationDepartment of Biological Sciences, Florida Institute of Technology, Melbourne 32901.en_US
dc.identifier.citationDhople AM, Lamoureux LC, Gardner GD. In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy. Indian Journal of Leprosy. 1991 Apr-Jun; 63(2): 166-79en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/54510
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshClofazimine --pharmacologyen_US
dc.subject.meshCulture Mediaen_US
dc.subject.meshDapsone --pharmacologyen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshLeprostatic Agents --pharmacologyen_US
dc.subject.meshLeprosy --drug therapyen_US
dc.subject.meshMiceen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshMycobacterium leprae --drug effectsen_US
dc.subject.meshRifabutinen_US
dc.subject.meshRifampin --pharmacologyen_US
dc.subject.meshRifamycins --pharmacologyen_US
dc.titleIn vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Leprosy