Role of HLA B27 in diagnosis of seronegative spondyloarthropathies.

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dc.contributor.authorSonkar, Gyanendra Kumaren_US
dc.contributor.authorUsha,en_US
dc.date.accessioned2007-10-01en_US
dc.date.accessioned2009-05-29T12:34:42Z
dc.date.available2007-10-01en_US
dc.date.available2009-05-29T12:34:42Z
dc.date.issued2007-10-01en_US
dc.description.abstractSeronegative Spondyloarthropathies (SSA) is a very common problem in our area. The main aim of present study was (1) to find the HLA B27 positivity in patients presenting with sacroileitis (2) to see the correlation of B27 positivity on haematological, radiological and extra articular manifestations. Total 110 patients of SSA were studied between July 2004 to June 2005. Routine haematological and immunological test were done by standard method. Total positivity of B27 in SSA was 43.63%, HLA B27 positivity was higher in children (68.75%). Sex wise analysis of B27 positive cases showed that 81.81% B27 positive patients were males. In HLA B27 positive cases lower spine, hip, sacroiliac, shoulder and knee joints were more involved (77.08%, 79.16%, 79.16%, 37.50% and 50.00% respectively). Urinary tract infection (UTI), diarrhoea and constipation were more common in B27 positive cases. Leukocytosis of neutrophilic type (33.33%), raised ESR (77.55%)., CRP positivity (63.63%) and anaemia (65.00%) were seen more frequently in B27 positive cases. In bilateral sacroiliitis diagnosed by X-ray, only 69.23% patient were B27 positive. Our study concludes that HLA B 27 positivity is higher in SSA seen in childhood and in young adult males. B27 positive patients have more severe disease and systemic manifestation Hence, male patients specially young adolescent or young adults with sacroileitis must be subjected for B27 typing.en_US
dc.description.affiliationUGC Advanced Immunodiagnostic Training and Research Center, Department of Pathology, IMS, BHU, Varanasi.en_US
dc.identifier.citationSonkar GK, Usha . Role of HLA B27 in diagnosis of seronegative spondyloarthropathies. Indian Journal of Pathology & Microbiology. 2007 Oct; 50(4): 908-13en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74739
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshArthritis, Reactive --complicationsen_US
dc.subject.meshChilden_US
dc.subject.meshConstipation --epidemiologyen_US
dc.subject.meshDiarrhea --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHLA-B27 Antigen --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshJoint Diseases --complicationsen_US
dc.subject.meshLeukocytosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSacroiliac Joint --pathologyen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSpinal Diseases --complicationsen_US
dc.subject.meshSpondylitis, Ankylosing --complicationsen_US
dc.subject.meshUrinary Tract Infections --epidemiologyen_US
dc.titleRole of HLA B27 in diagnosis of seronegative spondyloarthropathies.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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