Use of autologous umbilical cord blood transfusion in neonates undergoing surgical correction of congenital cardiac defects: A pilot study

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dc.contributor.authorSarin, Kunalen_US
dc.contributor.authorChauhan, Sandeepen_US
dc.contributor.authorBisoi, Akshay Kumaren_US
dc.contributor.authorHazarika, Anjalien_US
dc.contributor.authorMalhotra, Neenaen_US
dc.contributor.authorManek, Pratiken_US
dc.date.accessioned2019-12-02T09:43:23Z
dc.date.available2019-12-02T09:43:23Z
dc.date.issued2018-07
dc.description.abstractBackground: Blood transfusion requirement during neonatal open heart surgeries is universal. Homologous blood transfusion (HBT) in pediatric cardiac surgery is used most commonly for priming of cardiopulmonary bypass (CPB) system and for postoperative transfusion. To avoid the risks associated with HBT in neonates undergoing cardiac surgery, use of autologous umbilical cord blood (AUCB) transfusion has been described. We present our experience with the use of AUCB for neonatal cardiac surgery. Designs and Methods: Consecutive neonates scheduled to undergo cardiac surgery for various cardiac diseases who had a prenatal diagnosis made on the basis of a fetal echocardiography were included in this prospective observational study. After a vaginal delivery or a cesarean section, UCB was collected from the placenta in a 150-mL bag containing 5 mL of citrate–phosphate–dextrose–adenine-1 solution. The collected bag with 70–75 mL cord blood was stored at 2°C–6°C and tested for blood grouping and infections after proper labeling. The neonate's autologous cord blood was used for postcardiac surgery blood transfusion to replace postoperative blood loss. Results: AUCB has been used so far at our institute in 10 neonates undergoing cardiac surgery. The donor exposure in age and type of cardiac surgery-matched controls showed that the neonates not receiving autologous cord blood had a donor exposure to 5 donors (2 packed red blood cells [PRBCs], including 1 for CPB prime and 1 for postoperative loss, 1 fresh frozen plasma, 1 cryoprecipitate, and 1 platelet concentrate) compared to 1 donor for the AUCB neonate (1 PRBC for the CPB prime). Postoperative blood loss was similar in both the groups of matched controls and study group. Values of hemoglobin, total leukocyte count, platelet counts, and blood gas parameters were also similar. Conclusions: Use of AUCB for replacement of postoperative blood loss after neonatal cardiac surgery is feasible and reduces donor exposure to the neonate. Its use, however, requires a prenatal diagnosis of a cardiac defect by fetal echo and adequate logistic and psychological support from involved clinicians and the blood bank.en_US
dc.identifier.affiliationsDepartment of Cardiac Anaesthesiology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of CTVS, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsCN Centre, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Gynecology and Obstetrics, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationSarin Kunal, Chauhan Sandeep, Bisoi Akshay Kumar, Hazarika Anjali, Malhotra Neena, Manek Pratik. Use of autologous umbilical cord blood transfusion in neonates undergoing surgical correction of congenital cardiac defects: A pilot study. Annals of Cardiac Anaesthesia. 2018 Jul; 21(3): 270-274en_US
dc.identifier.issn0971-9784
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/185757
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume21en_US
dc.source.urihttps://dx.doi.org/10.4103/aca.ACA_194_17en_US
dc.subjectAutologous umbilical cord blood transfusionen_US
dc.subjecthomologous blood transfusionen_US
dc.subjectneonatal cardiac surgeryen_US
dc.titleUse of autologous umbilical cord blood transfusion in neonates undergoing surgical correction of congenital cardiac defects: A pilot studyen_US
dc.typeJournal Articleen_US
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