Insulin responses to varying hyperglycaemia in newly diagnosed non-insulin dependent diabetic patients.

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dc.contributor.authorSnehalatha, Cen_US
dc.contributor.authorTimothy, Hen_US
dc.contributor.authorMohan, Ven_US
dc.contributor.authorRamachandran, Aen_US
dc.contributor.authorViswanathan, Men_US
dc.date.accessioned1992-04-01en_US
dc.date.accessioned2009-05-31T04:08:30Z
dc.date.available1992-04-01en_US
dc.date.available2009-05-31T04:08:30Z
dc.date.issued1992-04-01en_US
dc.description.abstractThe effect of varying degrees of hyperglycaemia on insulin secretion was studied in newly diagnosed non-insulin dependent diabetic patients, stratified according to the fasting plasma glucose values. Of the 116 patients studied, 62 were non-obese and 54 obese. Insulin response patterns during 2h oral glucose tolerance test were analysed in comparison with the values in weight matched control subjects and also with respect to the degree of hyperglycaemia. The effect of hyperglycaemia on beta cell secretion differed in obese and non-obese patients. In the non-obese, fasting insulin levels were within normal range even in those with severe hyperglycaemia while the corresponding values in response to glucose stimulation showed a decreasing pattern. In obese patients, even fasting immunoreactive insulin (IRI) value was decreased and with increasing hyperglycaemia the reduction in IRI response to glucose stimulation was of greater magnitude compared to non-obese patients. Thus the modulating effect of obesity on insulin secretion appears to disappear with development of hyperglycaemia. The insulinogenic index was low in all the diabetic patients.en_US
dc.description.affiliationDept of Biochemistry, Diabetes Research Centre, Royapuram, Madras.en_US
dc.identifier.citationSnehalatha C, Timothy H, Mohan V, Ramachandran A, Viswanathan M. Insulin responses to varying hyperglycaemia in newly diagnosed non-insulin dependent diabetic patients. Journal of the Association of Physicians of India. 1992 Apr; 40(4): 240-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/94501
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshDiabetes Mellitus, Type 2 --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucose Tolerance Testen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperglycemia --blooden_US
dc.subject.meshInsulin --blooden_US
dc.subject.meshIslets of Langerhans --physiopathologyen_US
dc.subject.meshMaleen_US
dc.titleInsulin responses to varying hyperglycaemia in newly diagnosed non-insulin dependent diabetic patients.en_US
dc.typeJournal Articleen_US
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