Specificity in the regulation of eukaryotic gene transcription.
| dc.contributor.author | Padmanaban, G | |
| dc.date.accessioned | 2015-07-29T07:27:05Z | |
| dc.date.available | 2015-07-29T07:27:05Z | |
| dc.date.issued | 1993-03 | |
| dc.description.abstract | The regulation of eukaryotic gene transcription poses major challenges in terms of the innumerable protein factors required to ensure tissue or cell-type specificity. While this specificity is sought to be explained by the interaction of cis-acting DNA elements and the trans-acting protein factor(s), considerable amount of degeneracy has been observed in this interaction. Immunoglobulin heavy chain gene expression in Β cells and liver-specific gene expression are discussed as examples of this complexity in this article. Heterodimerization and post-translational modification of transcription factors and the organization of composite promoter elements are strategies by which diverse sets of genes can be regulated in a specific manner using a finite number of protein factors. | en_US |
| dc.identifier.citation | Padmanaban G. Specificity in the regulation of eukaryotic gene transcription. Journal of Biosciences. 1993 Mar; 18(1): 27-36. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/160847 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ias.ac.in/jarch/jbiosci/18/27-36.pdf | en_US |
| dc.subject | Transcription in eukaryotes | en_US |
| dc.subject | regulation | en_US |
| dc.title | Specificity in the regulation of eukaryotic gene transcription. | en_US |
| dc.type | Article | en_US |