Biliary atresia: outcome and management.

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dc.contributor.authorDavenport, Marken_US
dc.date.accessioned2006-09-29en_US
dc.date.accessioned2009-05-30T15:10:15Z
dc.date.available2006-09-29en_US
dc.date.available2009-05-30T15:10:15Z
dc.date.issued2006-09-29en_US
dc.description23 references.en_US
dc.description.abstractUntreated, biliary atresia remains a fatal condition of the newborn. Most present within four to six weeks of conjugated jaundice and acholic stools and, although still a challenging diagnosis to make, therein lies the opportunity of changing the course of this otherwise inexorable disease. The aim of surgery is to restore bile flow, alleviate jaundice and abbreviate the cholangiodestructive process within the liver. The Kasai portoenterostomy, introduced almost 50 years ago in Japan, aims to expose microscopic biliary ductules within the fibroinflammatory mass at the porta hepatis and restore bile drainage into a mobilised Roux loop. About 50% of infants with BA will be able to clear their jaundice following Kasai alone, given appropriately experienced surgeons and if performed prior to the onset of overt cirrhosis. They have a reasonable expectation of long-term survival to adulthood with a good quality-of-life. The remainder may be candidates for liver transplantation (where available) although donor organ shortage and immunosuppresion-related complications remain significant problems.en_US
dc.description.affiliationDepartment of Pediatric Surgery, King's College Hospital, London SE5 9RS, United Kingdom. Markdav2@ntlworld.comen_US
dc.identifier.citationDavenport M. Biliary atresia: outcome and management. Indian Journal of Pediatrics. 2006 Sep; 73(9): 825-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/83361
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshBiliary Atresia --diagnosisen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshHumansen_US
dc.subject.meshPortoenterostomy, Hepaticen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleBiliary atresia: outcome and management.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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