Clinical study of carbapenem sensitive and resistant Gram‑negative bacteremia in neutropenic and nonneutropenic patients: The first series from India.

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dc.contributor.authorGhafur, A K
dc.contributor.authorVidyalakshmi, P R
dc.contributor.authorKannaian, P
dc.contributor.authorBalasubramaniam, R
dc.date.accessioned2016-02-11T09:38:36Z
dc.date.available2016-02-11T09:38:36Z
dc.date.issued2014-10
dc.description.abstractOBJECTIVE: Carbapenem resistance is a growing global concern. There is a lack of published clinical studies on the topic from Indian subcontinent. Aim of this study was to analyze clinical profile of patients with carbapenem sensitive and resistant bacteremia among neutropenic and nonneutropenic patients. MATERIALS AND METHODS: Retrospective analysis of 141 patients who had carbapenem resistant or sensitive Gram‑negative bacteremia, identified over a period of 1‑year was done by medical records review, in Apollo Specialty Hospital, a 300‑bedded tertiary care Oncology, neurosurgical and orthopedic center in South India. RESULTS: Of the total 141 patients with Gram‑negative bacteremia, 44 had carbapenem resistant ones. Of these 44 patients, 17 were neutropenics (resistant neutropenic group) and 27 nonneutropenic patients (resistant nonneutropenic group). Of the 97 patients with carbapenem sensitive bacteremia, 43 were neutropenic (sensitive neutropenic group) and 54 nonneutropenics (sensitive nonneutropenic group). The 28 days mortality was significantly higher in carbapenem resistant bacteremic group compared to the sensitive one (P = 0.008). CONCLUSION: This is the first study from India comparing clinical features of patients with carbapenem sensitive and resistant blood stream infections. Patients with carbapenem resistant bacteremia had higher mortality compared to patients with sensitive bacteremia.en_US
dc.identifier.citationGhafur A K, Vidyalakshmi P R, Kannaian P, Balasubramaniam R. Clinical study of carbapenem sensitive and resistant Gram‑negative bacteremia in neutropenic and nonneutropenic patients: The first series from India. Indian Journal of Cancer. 2014 Oct-Dec; 51(4): 453-455.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/172458
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2014;volume=51;issue=4;spage=453;epage=455;aulast=Ghafuren_US
dc.subjectCarbapenem resistant and carbapenem resistant Gram‑negative bacteremiaen_US
dc.subjectclinical studyen_US
dc.subjectneutropenicsen_US
dc.subjectnonneutropenics Indiaen_US
dc.titleClinical study of carbapenem sensitive and resistant Gram‑negative bacteremia in neutropenic and nonneutropenic patients: The first series from India.en_US
dc.typeArticleen_US
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