The epidemiology of HIV-1 subtypes in infected patients from northeastern Thailand.

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dc.contributor.authorSrisuphanunt, Mayunaen_US
dc.contributor.authorSukeepaisarnchareon, Wisuten_US
dc.contributor.authorKucherer, Claudiaen_US
dc.contributor.authorPauli, Georgeen_US
dc.date.accessioned2009-05-27T15:41:09Z
dc.date.available2009-05-27T15:41:09Z
dc.date.issued2004-09-04en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractIn total, 117 HIV-1 infected patients from several provinces in Northeastern Thailand were analysed. All blood samples collected from individuals were confirmed by EIA and Western blot and partially by HIV-1 gag-, pol- and env-PCR. By serotyping with a V3-peptide ELISA, 108 (92.3%) of the sera samples belonged to subtype E, 9 (7.7%) were serotype B. For 10 Thai HIV-1 infections, the serotype and genotype were determined. The genotype was determined by phylogenetic analysis of directly sequenced PCR amplicons, 8 were subtype E, 2 subtype B. For these patients the serotype did correlate with the genotype. Tracing back the origin of Thai patients, it seems that most were infected within early years of the epidemic and the Thai subtype B infected patients have been imported directly from foreign countries via sexual contact. The findings suggest there are two district subtypes in Thailand with the majority being subtype E. The relatively high prevalence of subtype B in Northeastern Thailand may be due to the increasing intermix of the two strains (subtypes E and B) and the migration for employment from foreign countries. This may lead to public health concerns regarding surveillance of HIV-1 subtypes and the regulation of potentially infected workers returning from abroad to the country.en_US
dc.description.affiliationFaculty of Public Health, Mahidol University, Bangkok, Thailand. mayunaph@yahoo.comen_US
dc.identifier.citationSrisuphanunt M, Sukeepaisarnchareon W, Kucherer C, Pauli G. The epidemiology of HIV-1 subtypes in infected patients from northeastern Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health. 2004 Sep; 35(3): 641-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33406
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2004_35_3/26-3279.pdfen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshEpidemiology, Molecularen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Products, enven_US
dc.subject.meshGenotypeen_US
dc.subject.meshHIV Infections --blooden_US
dc.subject.meshHIV-1 --classificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshSequence Analysis, DNAen_US
dc.subject.meshSerotypingen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleThe epidemiology of HIV-1 subtypes in infected patients from northeastern Thailand.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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